Ischemic stroke and cancer: stroke severely impacts cancer patients, while cancer increases the number of strokes.
Ischemic stroke and cancer: stroke severely impacts cancer patients, while cancer increases the number of strokes.
复制标题
DOI：
10.3988/jcn.2011.7.2.53
复制
发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Bang OY;Seok JM;Kim SG;Hong JM;Kim HY;Lee J;Chung PW;Park KY;Kim GM;Chung CS;Lee KH
癌症和缺血性中风是老年人最常见的两种死亡原因，已有报道表明两者之间存在关联。然而，癌症患者卒中的主要发病机制尚不清楚，只能建立在准确了解癌症相关卒中特征的基础上。我们在这里回顾了最近关于癌症相关卒中患者的临床、实验室和放射学特征的研究。该综述包括癌症相关卒中的流行病学、潜在机制以及急性和预防性治疗。首先，讨论了癌症特异性卒中患者的卒中特征(临床和放射学特征)和系统性癌症(类型和范围)。其次，讨论了实验室检测在癌症特异性中风患者早期识别中的作用。具体地说，血清D-二聚体水平(作为高凝状态的标志)和经颅多普勒上的栓子信号(提示栓子起源)可能提供与癌症和抗凝相关的凝血障碍水平变化的线索。最后，讨论了癌症患者卒中治疗的策略，强调了在癌症相关性卒中中预防性策略(即抗凝剂的使用)比急性血管重建治疗的重要性。最近的研究表明，癌症相关卒中的特点与传统卒中不同。我们对癌症相关卒中的特点的了解对于正确处理这些患者是至关重要的。这篇综述中介绍的研究强调了个人化方法在治疗中风癌症患者中的重要性。
Cancer and ischemic stroke are two of the most common causes of death among the elderly, and associations between them have been reported. However, the main pathomechanisms of stroke in cancer patients are not well known, and can only be established based on accurate knowledge of the characteristics of cancer-related strokes. We review herein recent studies concerning the clinical, laboratory, and radiological features of patients with cancer-related stroke. This review covers the epidemiology, underlying mechanisms, and acute and preventive treatments for cancer-related stroke. First, the characteristics of stroke (clinical and radiological features) and systemic cancer (type and extent) in patients with cancer-specific stroke are discussed. Second, the role of laboratory tests in the early identification of patients with cancer-specific stroke is discussed. Specifically, serum D-dimer levels (as a marker of a hypercoagulable state) and embolic signals on transcranial Doppler (suggestive of embolic origin) may provide clues regarding changes in the levels of coagulopathy related to cancer and anticoagulation. Finally, strategies for stroke treatment in cancer patients are discussed, emphasizing the importance of preventive strategies (i.e., the use of anticoagulants) over acute revascularization therapy in cancer-related stroke. Recent studies have revealed that the characteristics of cancer-related stroke are distinct from those of conventional stroke. Our understanding of the characteristics of cancer-related stroke is essential to the correct management of these patients. The studies presented in this review highlight the importance of a personalized approach in treating stroke patients with cancer.
登录
查看更多内容
影响因子：
4.4
作者：
Kwon, Hyung-Min;Kang, Bong Su;Yoon, Byung-Woo
通讯作者：
Yoon, Byung-Woo
影响因子：
9.9
作者：
Baird, AE;Lövblad, KO;Warach, S
通讯作者：
Warach, S
影响因子：
6.7
作者：
Hron, Gregor;Kollars, Marietta;Weltermann, Ansgar
通讯作者：
Weltermann, Ansgar
影响因子：
8.3
作者：
Kim, Seon Gyeong;Hong, Ji Man;Bang, Oh Young
通讯作者：
Bang, Oh Young
影响因子：
6.2
作者：
Buccheri, GR;Torchio, P;Ferrigno, D
通讯作者：
Ferrigno, D