Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly Korean Women
Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly Korean Women
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肌肉减少症与韩国老年女性认知障碍和抑郁症有关
DOI：
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发表时间：
2018
影响因子：
1.4
通讯作者：
Hyunsik Kang
中科院分区：
文献类型：
--
作者：
Inhwan Lee;Jinkyung Cho;Haeryun Hong;Youngyun Jin;Donghyun Kim;Hyunsik Kang
背景：肌肉减少症与认知障碍和抑郁症的风险增加有关。在这项横断面研究中，我们在2014年至2015年间以201名社区居住的韩国女性（平均年龄74.0±6.8岁）为样本，调查了肌肉减少症与认知障碍（MCI）和抑郁症的关系。研究方法：分别采用韩国版简易精神状态检查量表和流行病学研究中心抑郁量表评估认知能力和抑郁。用测力计测量Grp强度。人口统计学、身体成分、教育、饮酒和心血管疾病史作为协变量进行评估。结果：根据肌肉减少状态计算MCI与抑郁的比值比（OR）和95%可信区间（95%CI）。与非肌肉减少症相比，肌肉减少症前和肌肉减少症女性MCI的OR分别为2.160（95%CI为0.840 - 5.554，P=0.030）和5.493（95%CI为1.854 - 16.270，P=0.002）。即使在调整年龄、体重指数（BMI）、瘦体重和教育程度后，MCI的肌肉减少症前OR仍然显著（P=0.030），而调整协变量后，MCI的肌肉减少症OR不再显著（P=0.084）。与非肌肉减少症相比，肌肉减少症前和肌肉减少症女性抑郁症的OR分别为3.750（95%CI为1.137 - 12.370，P=0.030）和4.687（95%CI为1.127-19.505，P=0.034）。即使在调整协变量后，肌肉减少症前和肌肉减少症对抑郁症的OR仍具有统计学显著性（分别为P=0.020和P=0.042）。结论：肌肉减少症与MCI和抑郁症在其他健康的社区老年韩国妇女中显着相关。
Background: Sarcopenia has been implicated in the increased risk for cognitive impairment and depression associated with aging. In this cross-sectional study, we investigated the relationship of sarcopenia with cognitive impairment (MCI) and depression in a sample of 201 community-dwelling Korean women (mean age of 74.0±6.8 yr) between 2014 and 2015. Methods: The Korean version of mini-mental state examination and the center for epidemiologic studies depression scale was used to assess cognitive performance and depression, respectively. Grp strength was measured with a dynamometer. Demographics, body composition, education, alcohol consumption, and history of cardiovascular diseases were assessed as covariates. Results: Odds ratio (OR) and 95% confidence interval (95% CI) of MCI and depression were calculated according to sarcopenia status. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of 0.840 – 5.554, P=0.030) and of 5.493 (95% CI of 1.854 – 16.270, P=0.002) for MCI. The OR of pre-sarcopenia for MCI remained significant (P=0.030) even after adjustments for age, body mass index (BMI), lean body mass, and education, while the OR of sarcopenia for MCI was no longer significant (P=0.084) when adjusted for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 3.750 (95% CI of 1.137 – 12.370, P=0.030) and of 4.687 (95% CI of 1.127–19.505, P=0.034) for depression. The ORs of pre-sarcopenia and sarcopenia for depression remained statistically significant (P=0.020 and P=0.042, respectively) even after adjusted for the covariates Conclusion: Sarcopenia was significantly associated with MCI and depression in otherwise healthy community dwelling elderly Korean women.
DOI：
10.1093/ajcn/83.1.146
发表时间：
2006
期刊：
The American journal of clinical nutrition
影响因子：
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作者：
Y. Hsu;S. Venners;H. Terwedow;Yan Feng;T. Niu;Zhiping Li;N. Laird;Joseph D. Brain;S. Cummings;M. Bouxsein;C. Rosen;Xiping Xu
通讯作者：
Y. Hsu;S. Venners;H. Terwedow;Yan Feng;T. Niu;Zhiping Li;N. Laird;Joseph D. Brain;S. Cummings;M. Bouxsein;C. Rosen;Xiping Xu
影响因子：
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作者：
Burns, Jeffrey M.;Johnson, David K.;Watts, Amber;Swerdlow, Russell H.;Brooks, William M.
通讯作者：
Brooks, William M.
影响因子：
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作者：
Barnes, DE;Alexopoulos, GS;Yaffe, K
通讯作者：
Yaffe, K