Reduced lean mass in early Alzheimer disease and its association with brain atrophy.
Reduced lean mass in early Alzheimer disease and its association with brain atrophy.
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DOI：
10.1001/archneurol.2010.38
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发表时间：
2010-04
影响因子：
--
通讯作者：
Brooks, William M.
中科院分区：
文献类型：
--
作者：
Burns, Jeffrey M.;Johnson, David K.;Watts, Amber;Swerdlow, Russell H.;Brooks, William M.
阿尔茨海默氏病 (AD) 与身体成分改变有关，在痴呆症发病前几年就开始出现体重减轻。我们检查了早期 AD 和非痴呆个体的身体成分及其与认知和脑容量的关系。堪萨斯大学医学院的横断面病例对照研究阿尔茨海默病和记忆项目的参与者为非痴呆症（临床痴呆评级 [CDR] 0，n=70）和早期 AD（CDR 0.5 或 1，n=70）参与者。参与者接受脑磁共振成像 (MRI)、神经心理学测试和双能 X 射线吸收测定法 (DEXA) 评估，以确定全身脂肪量和瘦体重。体重指数（BMI）是根据身高和体重确定的。在控制性别后，与非痴呆对照相比，AD 早期的瘦体重有所减少（F=7.73，p=0.006）。在控制年龄和性别的情况下，全脑体积（β=0.20，p<0.001）、白质体积（β=0.19，p<0.001）和整体认知能力（β=0.12，p=0.007）与瘦体重（因变量）相关。各组之间的身体总脂肪和身体脂肪百分比没有差异，也与认知和脑容量相关。 AD 中瘦体重的损失加速，并与脑萎缩和认知能力相关，这可能是 AD 病理生理学的直接或间接结果，或者是通过 AD 和肌肉减少症共有的机制。
Alzheimer’s disease (AD) is associated with altered body composition with weight loss beginning years prior to the onset of dementia. We examined body composition in early AD and nondemented individuals and its relation to cognition and brain volume. Cross-sectional, case-control study Alzheimer and Memory Program at the University of Kansas School of Medicine Nondemented (Clinical Dementia Rating [CDR] 0, n=70) and early-stage AD (CDR 0.5 or 1, n=70) participants. Participants were evaluated with brain magnetic resonance imaging (MRI), neuropsychological testing and dual energy x-ray absorptiometry (DEXA) to determine whole-body fat mass and lean mass. Body mass index (BMI) was determined from height and weight. Lean mass was reduced in early AD compared to nondemented controls (F=7.73, p=0.006) after controlling for sex. Whole-brain volume (beta=0.20, p<0.001), white matter volume (beta=0.19, p<0.001), and global cognitive performance (beta=0.12, p=0.007) were associated with lean mass (dependent variable) when controlling for age and sex. Total body fat and percent body fat were not different across groups or related to cognition and brain volume. Loss of lean mass is accelerated in AD and associated with brain atrophy and cognitive performance perhaps as a direct or indirect consequence of AD pathophysiology or through shared mechanisms common to both AD and sarcopenia.
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影响因子：
9.9
作者：
Burns JM;Cronk BB;Anderson HS;Donnelly JE;Thomas GP;Harsha A;Brooks WM;Swerdlow RH
通讯作者：
Swerdlow RH
影响因子：
5.3
作者：
Adlard, PA;Perreau, VM;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
9.9
作者：
Buchman, A. S.;Schneider, J. A.;Bennett, D. A.
通讯作者：
Bennett, D. A.
DOI：
10.1111/j.1532-5415.2005.00522.x
发表时间：
2006-01-01
影响因子：
6.3
作者：
Kuo, HK;Jones, RN;Lipsitz, LA
通讯作者：
Lipsitz, LA
影响因子：
--
作者：
Johnson, David K.;Wilkins, Consuelo H.;Morris, John C.
通讯作者：
Morris, John C.