Government response moderates the mental health impact of COVID-19: A systematic review and meta-analysis of depression outcomes across countries.

Government response moderates the mental health impact of COVID-19: A systematic review and meta-analysis of depression outcomes across countries.
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DOI:
10.1016/j.jad.2021.04.050
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发表时间:
2021-07-01
影响因子:
6.6
通讯作者:
McIntyre RS
McIntyre RS
中科院分区:
医学2区
文献类型:
--
作者:
Lee Y;Lui LMW;Chen-Li D;Liao Y;Mansur RB;Brietzke E;Rosenblat JD;Ho R;Rodrigues NB;Lipsitz O;Nasri F;Cao B;Subramaniapillai M;Gill H;Lu C;McIntyre RS

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2019冠状病毒病大流行是一场公共卫生、经济和精神健康危机。我们假设,政府及时实施严格的措施来减少病毒传播将有利于心理健康,抑郁症状发生率的降低证明了这一点(即患者健康问卷[PHQ]-9≥10,PHQ-2≥3)。本文的系统评价(PROSPERO CRD42020200647)评估了在33个国家(k=114, N=640,037)中,政府规定的应对COVID-19的严格性和及时性的差异在多大程度上缓解了抑郁症状的患病率。我们纳入了来自6个中低收入国家、9个中高收入国家和18个高收入国家的数据。使用牛津COVID-19政府应对(“严格性”)指数对政府实施的严格性和及时性进行了操作。有临床显著抑郁症状的研究参与者的总比例为21.39% (95% CI 19.37-23.47)。在政府及时实施严格政策的国家,临床显著抑郁症状的患病率明显较低。在纳入研究开始时的全国COVID病例频率、医疗保健可及性和质量指数以及将COVID患者纳入研究后,政府反应的调节效应仍然显著。可能混淆我们的结果的因素包括,例如,封锁持续时间的差异,缺乏研究参与者和结果评估者的盲法,以及对抑郁症状严重程度的回顾性评估。采取严格措施遏制COVID-19传播的政府不仅使其人口的身体健康受益,而且使其心理健康受益。
The COVID-19 pandemic represents a public health, economic and mental health crisis. We hypothesized that timely government implementation of stringent measures to reduce viral transmission would benefit mental health, as evidenced by reduced rates of depressive symptoms (i.e., Patient Health Questionnaire [PHQ]-9≥10, PHQ-2≥3). The systematic review herein (PROSPERO CRD42020200647) evaluated to what extent differences in government-imposed stringency and timeliness of response to COVID-19 moderate the prevalence of depressive symptoms across 33 countries (k=114, N=640,037). We included data from six lower-middle-income countries, nine upper-middle-income countries, and 18 higher-income countries. Government-imposed stringency and timeliness in response were operationalized using the Oxford COVID-19 Government Response (“Stringency”) Index. The overall proportion of study participants with clinically significant depressive symptoms was 21.39% (95% CI 19.37–23.47). The prevalence of clinically significant depressive symptoms was significantly lower in countries wherein governments implemented stringent policies promptly. The moderating effect of government response remained significant after including the national frequency of COVID cases at the time of study commencement, Healthcare Access and Quality index, and the inclusion of COVID patients in the study. Factors that may have confounded our results include, for example, differences in lockdown duration, lack of study participant and outcome assessor blinding, and retrospective assessment of depressive symptom severity. Governments that enacted stringent measures to contain the spread of COVID-19 benefited not only the physical, but also the mental health of their population.
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