The mechanism of vascular calcification - a systematic review.
The mechanism of vascular calcification - a systematic review.
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DOI：
10.12659/msm.882181
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Myśliwiec M
中科院分区：
文献类型：
--
作者：
Karwowski W;Naumnik B;Szczepański M;Myśliwiec M
血管的钙化降低了它们的弹性，影响心血管系统的血液动力学参数。动脉高血压、心脏肥大、缺血性心脏病或外周动脉疾病的发展显著增加了60岁以上患者的死亡率。血管壁中钙沉积的进展阶段和积聚程度是缺血事件的关键风险因素。血管钙化是一个活跃而复杂的过程，涉及许多负责动脉壁中钙沉积的机制。它们导致动脉硬度和脉搏波速度增加，这反过来又增加了心血管疾病的发病率和死亡率。深入研究和全面了解血管钙化机制可能是建立有效的血管保护治疗的关键。本研究的目的是对代谢和激素紊乱对血管钙化发展的影响的最新研究进行全面调查。由于与骨组织中发生的过程非常相似，用于骨质疏松症治疗的药物（骨化三醇、雌二醇、双膦酸盐）可能会干扰血管壁中发生的过程。另一方面，用于治疗心血管疾病的药物（他汀类药物、血管紧张素转化酶抑制剂、华法林、肝素）可能对骨组织代谢产生影响。最佳控制钙和磷酸盐浓度的努力对终末期肾病患者也是有益的，对他们来说，血管钙化仍然是一个主要问题。
Calcification of vessels reduces their elasticity, affecting hemodynamic parameters of the cardiovascular system. The development of arterial hypertension, cardiac hypertrophy, ischemic heart disease or peripheral arterial disease significantly increases mortality in patients over 60 years of age. Stage of advancement and the extent of accumulation of calcium deposits in vessel walls are key risk factors of ischemic events. Vascular calcification is an active and complex process that involves numerous mechanisms responsible for calcium depositions in arterial walls. They lead to increase in arterial stiffness and in pulse wave velocity, which in turn increases cardiovascular disease morbidity and mortality. In-depth study and thorough understanding of vascular calcification mechanisms may be crucial for establishing an effective vasculoprotective therapy. The aim of this study was to present a comprehensive survey of current state-of-the-art research into the impact of metabolic and hormonal disorders on development of vascular calcification. Due to strong resemblance to the processes occurring in bone tissue, drugs used for osteoporosis treatment (calcitriol, estradiol, bisphosphonates) may interfere with the processes occurring in the vessel wall. On the other hand, drugs used to treat cardiovascular problems (statins, angiotensin convertase inhibitors, warfarin, heparins) may have an effect on bone tissue metabolism. Efforts to optimally control calcium and phosphate concentrations are also beneficial for patients with end-stage renal disease, for whom vessel calcification remains a major problem.
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影响因子：
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作者：
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通讯作者：
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