Choline PET and PET/CT in Primary Diagnosis and Staging of Prostate Cancer.
Choline PET and PET/CT in Primary Diagnosis and Staging of Prostate Cancer.
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DOI：
10.7150/thno.4008
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发表时间：
2012
期刊：
影响因子：
12.4
通讯作者：
Krause BJ
中科院分区：
文献类型：
--
作者：
Schwarzenböck S;Souvatzoglou M;Krause BJ
使用[11 C]和[18 F]标记的胆碱衍生物的PET和PET/CT越来越多地用于原发性和复发性前列腺癌的成像。虽然在许多研究中已经检查了患有前列腺癌生化复发的患者的PET和PET/CT与[11 C]-和[18F]-标记的胆碱衍生物，证明其重要性日益增加，但其在前列腺癌原发分期中的作用仍然是一个有争议的问题。形态学和功能成像技术，如CT，MRI和TRUS已证明只有有限的准确性诊断原发性前列腺癌。PET和PET/CT分子成像可能会提高原发性前列腺癌定位的准确性。相当多的研究已经检查了PET/CT与[11 C]-和[18 F]-标记的胆碱衍生物诊断原发性前列腺癌的价值，结果不一。使用[11 C]-和[18 F]胆碱PET和PET/CT只能以中等灵敏度检测原发性前列腺癌。检测率取决于肿瘤的结构。由于部分体积效应，检测也受到相当数量的微小癌的限制。因此，小的和部分外皮状肿瘤往往不能被可视化。此外，良性病变如前列腺炎、高度上皮内瘤变（HGPIN）或前列腺增生之间的区别并不总是可能的。因此，目前，常规使用[11 C]和[18 F]标记胆碱衍生物的PET/CT不能推荐作为高危男性原发性前列腺癌的一线筛查程序。胆碱PET和PET/CT的潜在应用可能是提高临床疑似前列腺癌的检出率，其中多次阴性前列腺活检，例如在准备集中再活检时，并且可能在未来关于初次手术和放射治疗的患者分层中发挥作用。
PET and PET/CT using [11C]- and [18F]-labelled choline derivates is increasingly being used for imaging of primary and recurrent prostate cancer. While PET and PET/CT with [11C]- and [18F]-labelled choline derivates in patients suffering from biochemical recurrence of prostate cancer has been examined in many studies that demonstrate an increasing importance, its role in the primary staging of prostate cancer is still a matter of debate. Morphological and functional imaging techniques such as CT, MRI and TRUS have demonstrated only limited accuracy for the diagnosis of primary prostate cancer. Molecular imaging with PET and PET/CT could potentially increase accuracy to localize primary prostate cancer. A considerable number of studies have examined the value of PET/CT with [11C]- and [18F]- labelled choline derivates for the diagnosis of primary prostate cancer with mixed results. Primary prostate cancer can only be detected with moderate sensitivity using [11C]- and [18F]choline PET and PET/CT. The detection rate depends on the tumour configuration. Detection is also limited by a considerable number of microcarcinomas that cannot be detected due to partial volume effects. Therefore small and in part rind-like tumours can often not be visualized. Furthermore, the differentiation between benign changes like prostatitis, high-grade intraepithelial neoplasia (HGPIN) or prostatic hyperplasia is not always possible. Therefore, at the present time, the routine use of PET/CT with [11C]- and [18F]-labelled choline derivates cannot be recommended as a first-line screening procedure for primary prostate cancer in men at risk. A potential application of choline PET and PET/CT may be to increase the detection rate of clinically suspected prostate cancer with multiple negative prostate biopsies, for example in preparation of a focused re-biopsy and may play a role in patient stratification with respect to primary surgery and radiation therapy in the future.
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DOI：
10.2967/jnumed.110.077941
发表时间：
2011-01
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
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影响因子：
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作者：
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发表时间：
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影响因子：
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