Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.
Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.
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在中国社区队列中，婴儿 BMI 在 2 岁时达到峰值，可作为超重和肥胖的预测因子
DOI：
10.1136/bmjopen-2016-015122
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发表时间：
2017-10-06
期刊：
影响因子：
2.9
通讯作者：
Wu Z
中科院分区：
文献类型：
--
作者：
Sun J;Nwaru BI;Hua J;Li X;Wu Z
婴儿体重指数（BMI）峰值已被证明是预测美国和欧洲人群儿童肥胖风险的有用指标。但在中国尚未进行评估。我们在中国纵向队列中描述了婴儿BMI轨迹，并评估了BMI峰值是否可以预测2岁时的超重和肥胖。对上海市区2073例健康足月儿进行了6-12次体重和身长的连续测量。使用多项式回归模型，测量用于估计从出生到13.5个月的BMI生长曲线。BMI峰值特征，包括年龄（月）和幅度（BMI，kg/m2）在峰值和峰前速度（kg/m2/月），估计。婴儿BMI峰值与2岁时儿童BMI之间的关系采用二元Logistic分析进行了研究。BMI峰值时的平均年龄为7.61个月，幅度为18.33 kg/m2。男孩（n=1022）的平均峰值BMI（18.60 vs 18.07 kg/m2，p<0.001）和平均峰值达到时间（7.54 vs 7.67个月，p<0.05）均高于女孩（n=1051）。随着峰值BMI增加1 kg/m2和峰值时间增加1个月，2岁时超重的风险分别增加2.11倍（OR 3.11; 95%CI 2.64 - 3.66）和35%（OR 1.35; 95%CI 1.21 - 1.50）。同样，较高的BMI值（OR 2.69; 95% CI 2.00 - 3.61）和婴儿BMI峰值出现时间较晚（OR 1.35; 95% CI 1.08 - 1.68）与2岁时儿童肥胖风险增加相关。结果表明，婴儿BMI峰值对预测上海市区儿童早期超重和肥胖有一定的参考价值。因为这是中国第一个以社区为基础的队列研究，未来的研究需要检查中国其他地区的婴儿人口。
Infant body mass index (BMI) peak has proven to be a useful indicator for predicting childhood obesity risk in American and European populations. However, it has not been assessed in China. We characterised infant BMI trajectories in a Chinese longitudinal cohort and evaluated whether BMI peak can predict overweight and obesity at age 2 years. Serial measurements (n=6–12) of weight and length were taken from healthy term infants (n=2073) in a birth cohort established in urban Shanghai. Measurements were used to estimate BMI growth curves from birth to 13.5 months using a polynomial regression model. BMI peak characteristics, including age (in months) and magnitude (BMI, in kg/m2) at peak and prepeak velocities (in kg/m2/month), were estimated. The relationship between infant BMI peak and childhood BMI at age 2 years was examined using binary logistic analysis. Mean age at peak BMI was 7.61 months, with a magnitude of 18.33 kg/m2. Boys (n=1022) had a higher average peak BMI (18.60 vs 18.07 kg/m2, p<0.001) and earlier average achievement of peak value (7.54 vs 7.67 months, p<0.05) than girls (n=1051). With 1 kg/m2 increase in peak BMI and 1 month increase in peak time, the risk of overweight at age 2 years increased by 2.11 times (OR 3.11; 95% CI 2.64 to 3.66) and 35% (OR 1.35; 95% CI 1.21 to 1.50), respectively. Similarly, higher BMI magnitude (OR 2.69; 95% CI 2.00 to 3.61) and later timing of infant BMI peak (OR 1.35; 95% CI 1.08 to 1.68) were associated with an increased risk of childhood obesity at age 2 years. We have shown that infant BMI peak is valuable for predicting early childhood overweight and obesity in urban Shanghai. Because this is the first Chinese community-based cohort study of this nature, future research is required to examine infant populations in other areas of China.
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