Axonogenesis in the medaka embryonic brain
Axonogenesis in the medaka embryonic brain
复制标题
青鳉胚胎脑中的轴突发生
DOI：
10.1002/cne.20220
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发表时间：
2004
影响因子：
2.5
通讯作者：
Hironobu Ito
中科院分区：
文献类型：
--
作者：
Y. Ishikawa;T. Kage;N. Yamamoto;M. Yoshimoto;Takako Yasuda;Atsuko Matsumoto;K. Maruyama;Hironobu Ito
为了了解脊椎动物轴突发生的一般模式，我们研究了硬骨鱼青（Oryzias latipes）胚胎脑中的轴突发生，并与斑马鱼和小鼠的研究结果进行了比较。使用细胞表面标记物（HNK-1）和乙酰化微管蛋白的抗体对轴突和胞体进行免疫细胞化学染色，并通过亲脂性染料逆行和顺行标记进行可视化。纤维系统的发展与胚胎脑的纵向和横向细分的组织相关。受精后38小时，第一个轴突从联脑被盖延伸，在神经杆的腹侧纵带形成第一个纤维束（内侧脊髓束）。在神经管中，在整个大脑中的两对纵向纤维系统，一个腹侧系列和一个背侧或中间系列，和四对横向纤维束在吻侧脑轴突生产的第一个16小时期间顺序形成。其中一条背侧纵束的分支在后期回缩消失。其中一条横束位于端脑和下丘脑。青鳉脑纵向纤维系统的总体模式与小鼠相似，但与斑马鱼明显不同。我们建议，在斑马鱼腹道报告部分属于背纤维系统，并在所有脊椎动物的大脑纵向纤维系统通过保守的遗传和发育程序定义的共同布局。神经学比较杂志476：240-253，2004.© 2004 Wiley利斯公司
In order to know the general pattern of axonogenesis in vertebrates, we examined axonogenesis in the embryonic brain of a teleost fish, medaka (Oryzias latipes), and the results were compared with previous studies in zebrafish and mouse. The axons and somata were stained immunocytochemically using antibodies to a cell surface marker (HNK‐1) and acetylated tubulin and visualized by retrograde and anterograde labeling with a lipophilic dye. The fiber systems developed correlating with the organization of the longitudinal and transverse subdivisions of the embryonic brain. The first axons extended from the synencephalic tegmentum, forming the first fiber tract (fasciculus longitudinalis medialis) in the ventral longitudinal zone of the neural rod, 38 hours after fertilization. In the neural tube, throughout the entire brain two pairs of longitudinal fiber systems, one ventral series and one dorsal or intermediate series, and four pairs of transverse fiber tracts in the rostral brain were formed sequentially during the first 16 hours of axon production. In one of the dorsal longitudinal tracts, its branch retracted and disappeared at later stages. One of the transverse tracts was found to course in the telencephalon and hypothalamus. The overall pattern of the longitudinal fiber systems in medaka brain is similar to that in mouse, but apparently different from that in zebrafish. We propose that a ventral tract reported in zebrafish partially belongs to the dorsal fiber system, and that the longitudinal fiber systems in all vertebrate brains pass through a common layout defined by conserved genetic and developmental programs. J. Comp. Neurol. 476:240–253, 2004. © 2004 Wiley‐Liss, Inc.
影响因子：
4.6
作者：
Stephen W. Wilson;L. S. Ross;T. Parrett;S. Easter
通讯作者：
Stephen W. Wilson;L. S. Ross;T. Parrett;S. Easter
影响因子：
56.9
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者：
STANFIELD, BB
HNK-1 标志着非洲爪蟾最早的轴突生长。
DOI：
10.1016/0165-3806(89)90135-1
发表时间：
1989
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Nordlander,RH
通讯作者：
Nordlander,RH