Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort.
Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort.
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DOI：
10.1016/j.neurobiolaging.2021.04.007
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Hamilton O;Cox SR;Ballerini L;Bastin ME;Corley J;Gow AJ;Muñoz Maniega S;Redmond P;Valdés Hernández MDC;Wardlaw JM;Deary IJ
SVD负担越大，所有主要认知领域的能力越差。由于与一般能力的协方差，SVD与记忆和视觉空间相关。然而，SVD与处理速度的关联与一般能力无关。连续的放射学变量提高了SVD负荷量化的保真度。所有主要的认知领域都应该在SVD研究和临床环境中进行测试。脑血管病（SVD）是血管性认知障碍的主要原因，然而，SVD相关认知缺陷的确切性质及其与脑结构变化的关系尚不清楚。我们使用1936年洛锡安出生队列（n = 540，年龄：72.6±0.7岁）的数据，结合SVD的计算体积和视觉评价的MRI标记来量化SVD的总负担。我们发现总SVD负担与一般认知能力（标准化β: -0.363; 95%CI: [-0.49, -0.23]; p(FDR) < 0.001）、处理速度（-0.371 [-0.50,-0.24];p(FDR) < 0.001）、言语记忆（-0.265;[-0.42,-0.11];p(FDR) = 0.002）和视觉空间能力（-0.170;[-0.32,-0.02];p(FDR) = 0.029）呈负相关。在考虑了与一般认知能力的协方差后，仅SVD负担与处理速度之间存在关联（-0.325;[-0.61,-0.04];p(FDR) = 0.029）。这表明SVD与较差的处理速度的关联不是由其与较差的一般认知能力的关联驱动的，而是独立的。处理速度的测试可能对奇异值分解的认知影响特别敏感，但所有主要的认知领域都应该进行测试，以确定与奇异值分解相关的全方位认知特征。
Greater SVD burden associates with poorer abilities in all major cognitive domains. SVD associates with memory and visuospatial due to covariance with general ability. However, SVD’s association with processing speed is independent of general ability. Continuous radiological variables improve fidelity of SVD burden quantification. All major cognitive domains should be tested in SVD research and clinical settings. Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n = 540; age: 72.6 ± 0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardized β: -0.363; 95%CI: [-0.49, -0.23]; p(FDR) < 0.001), processing speed (-0.371 [-0.50, -0.24]; p(FDR) < 0.001), verbal memory (-0.265; [-0.42, -0.11]; p(FDR) = 0.002), and visuospatial ability (-0.170; [-0.32, -0.02]; p(FDR) = 0.029). Only the association between SVD burden and processing speed remained after accounting for covariance with general cognitive ability (-0.325; [-0.61, -0.04]; p(FDR) = 0.029). This suggests that SVD's association with poorer processing speed is not driven by, but is independent of its association with poorer general cognitive ability. Tests of processing speed may be particularly sensitive to the cognitive impact of SVD, but all major cognitive domains should be tested to determine the full range of SVD-related cognitive characteristics.
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影响因子：
4.6
作者：
Ballerini L;Lovreglio R;Valdés Hernández MDC;Ramirez J;MacIntosh BJ;Black SE;Wardlaw JM
通讯作者：
Wardlaw JM
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM
影响因子：
4.2
作者：
Ballerini, Lucia;Booth, Tom;Wardlaw, Joanna
通讯作者：
Wardlaw, Joanna
影响因子：
4.8
作者：
Huijts M;Duits A;van Oostenbrugge RJ;Kroon AA;de Leeuw PW;Staals J
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