Comparison of five artificial skin surface film liquids for assessing dermal bioaccessibility of metals in certified reference soils.
Comparison of five artificial skin surface film liquids for assessing dermal bioaccessibility of metals in certified reference soils.
复制标题
比较五种人造皮肤表面薄膜液体，用于评估经过认证的参考土壤中金属的皮肤生物可及性。
DOI：
10.1016/j.scitotenv.2019.07.281
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
G. Zagury
中科院分区：
文献类型：
--
作者：
Carlos A Marin Villegas;Mert Guney;G. Zagury
此前，与口服/吸入接触相比，皮肤接触金属受到的关注较少。尽管如此，对于某些污染物和暴露情况来说，人类健康风险仍然很大。本研究的目的是 (1) 表征两种经过认证的参考土壤（SQC001、BGS 102）； (2) 使用三种合成汗液配方（EN 1811，pH6.5（汗液 A）、NIHS 96-10，pH4.7（汗液 B）和更复杂的含有氨基酸的 pH5.5 配方（汗液 C））和两种皮脂配方，通过体外测定评估 Cr、Ni、Pb 和 Zn 的真皮生物可及性。汗液中金属的生物可及性依次为汗液 B>汗液 C>汗液 A，归因于汗液 B 的 pH 值较低。两种皮脂配方中 Ni 和 Pb 的皮肤生物可及性均低于 1%，Cr 和 Zn 的皮肤生物可及性低于 9%，这可能是由于金属对非极性脂质的亲和力较低。必须指出的是，与任何合成汗液配方相比，用合成皮脂提取时，BGS 102 中的生物可利用锌含量更高。 SQC001 汗液中的金属生物可及性（使用汗液 B 时锌高达 76.6%）显着高于 BGS 102（所有元素和所有汗液配方的范围为 0.02% 至 1.3%），这归因于参考土壤 BGS 102 的 pH 值较高、有机碳较高和阳离子交换能力较高。添加金属的皮脂配方通常导致金属回收率较低（锌除外），这可能解释了总体较低的金属回收率。皮脂的生物可及性值。皮脂和汗液配方以及土壤特性似乎控制着金属的体外生物可及性。
Dermal exposure to metals has previously received less attention than oral/inhalation exposure. Nonetheless, human health risk is significant for certain contaminants and exposure scenarios. The present study aims to (1) characterize two certified reference soils (SQC001, BGS 102); and (2) assess Cr, Ni, Pb, and Zn dermal bioaccessibilityvia in vitroassays using three synthetic sweat formulations (EN 1811, pH 6.5 (Sweat A), NIHS 96-10, pH 4.7 (Sweat B), and a more complex pH 5.5 formulation containing amino acids (Sweat C)) and two sebum formulations. Metals bioaccessibility in sweat followed Sweat B > Sweat C > Sweat A, attributed to sweat B lower pH. Dermal bioaccessibility in both sebum formulations was lower than 1% for Ni and Pb and below 9% for Cr and Zn, possibly due to low affinity of metals for non-polar lipids. It must be noted that bioaccessible Zn in BGS 102 was higher when extracted with synthetic sebum compared to any of the synthetic sweat formulations. Metal bioaccessibility in sweat was considerably higher for SQC001 (up to 76.6% for Zn using Sweat B) than for BGS 102 (ranging between 0.02 and 1.3% for all elements and all sweat formulations), attributed to higher pH, higher organic carbon, and higher cation exchange capacity of reference soil BGS 102. Sebum formulations spiked with metals generally entailed low metal recovery (except for Zn), which may explain overall low bioaccessibility values for sebum. Sebum and sweat formulation, and soil properties seem to controlin vitrodermal bioaccessibility of metals.
合金中金属的生物可及性：三种替代生物流体的评估。
DOI：
10.1016/j.envpol.2013.10.006
发表时间：
2014
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Hillwalker,WendyE;Anderson,KimA
通讯作者：
Anderson,KimA