Inflammation at the interface of physical and neuropsychiatric outcomes: Investigation of neuroendocrine regulatory pathways to inform therapeutics.
Inflammation at the interface of physical and neuropsychiatric outcomes: Investigation of neuroendocrine regulatory pathways to inform therapeutics.
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DOI：
10.1016/j.bbi.2020.04.076
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发表时间：
2020-08
期刊：
影响因子：
--
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文献类型：
--
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越来越多的证据强调了身体和心理疾病的共同发病率及其在疾病进展和治疗考虑中的重要性。神经和免疫系统的双向关系被证明是许多此类疾病的基础。我们进行了一系列研究，以调查炎症及其神经内分泌调节机制，这些机制是慢性身体状况和疾病（包括代谢紊乱，心血管疾病（CVD）和人类免疫缺陷病毒（HIV）感染）中情感和认知结果的基础。本文总结了我们在2019年第10届世界神经科学大会上发表的题为“炎症与大脑对话中的拨号”的研讨会上发表的研究结果，并分为五个主要部分：1。免疫功能障碍伴中枢神经系统（CNS）症状; 2.抑郁症和抑郁症状的免疫失调; 3.脑免疫联系中炎症调节的神经内分泌途径; 4.共病条件和协变量在身体和精神健康结果的接口;和5。临床和治疗意义。这篇简短的综述的主要目的是通过总结我们以前的研究结果，而不是全面的综述，同时承认关于这一主题的大量文献，强调炎症和免疫失调在身体和神经精神疾病之间的作用。
Increasing evidence highlights the co-morbidity of physical and psychological illnesses and its significance in disease progression and therapeutic considerations. The bidirectional relationship of the nervous and immune systems is shown to underlie many of such conditions. We conducted a series of studies to investigate inflammation and its neuroendocrine regulatory mechanisms that underlie affective and cognitive outcomes in chronic physical conditions and diseases, including metabolic disorders, cardiovascular disease (CVD) and human immunodeficiency virus (HIV) infection. This paper summarizes our published findings as presented in the symposium titled, Dialing in the Dialogue Between Inflammation and the Brain at the 10th World Congress of Neuroscience in 2019 and is organized in five main sections: 1. Immune dysfunctions with central nervous system (CNS) symptoms; 2. Immune dysregulation underlying depression and depressive symptoms; 3. Neuroendocrine pathways of inflammation regulation in the brain-immune link; 4. Co-morbid conditions and covariates in the interface of physical and mental health outcomes; and 5. Clinical and therapeutic implications. The primary aim of this brief review is to highlight the role of inflammation and immune dysregulation at the interface between physical and neuropsychiatric conditions by summarizing our previous findings rather than it being a comprehensive review, while acknowledging a large body of literature on this topic.
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Grant, Igor
DOI：
10.1016/j.bbi.2015.08.012
发表时间：
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期刊：
Brain, behavior, and immunity
影响因子：
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