Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.

Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.
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人脑的体内扩散MRI:技术挑战和最新进展。

DOI:
10.1002/nbm.3941
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发表时间:
2019-04
期刊:
影响因子:
2.9
通讯作者:
Aggarwal M
Aggarwal M
中科院分区:
医学3区
文献类型:
--
作者:
Roebroeck A;Miller KL;Aggarwal M

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这篇综述讨论了离体扩散磁共振成像(dMRI)作为一个重要的研究工具,神经解剖学调查和在体内dMRI技术的验证,重点是对人脑。我们回顾了死后组织的特性所带来的挑战,并讨论了最先进的组织制备方法以及脉冲序列和采集技术的最新进展,以解决这些问题。然后,我们回顾了最近的离体dMRI研究的人脑,突出验证的白色物质的方向估计和大的皮层下结构的图谱和映射。我们还特别强调了分层灰质结构的描绘与离体dMRI,因为这个应用程序说明了它的中尺度分辨率在大视场的强度。最后,我们对该领域的未来和潜在方向进行了讨论和展望。
This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on the human brain. We review the challenges posed by the properties of post‐mortem tissue, and discuss state‐of‐the‐art tissue preparation methods and recent advances in pulse sequences and acquisition techniques to tackle these. We then review recent ex vivo dMRI studies of the human brain, highlighting the validation of white matter orientation estimates and the atlasing and mapping of large subcortical structures. We also give particular emphasis to the delineation of layered gray matter structure with ex vivo dMRI, as this application illustrates the strength of its mesoscale resolution over large fields of view. We end with a discussion and outlook on future and potential directions of the field.
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