Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.
Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.
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人脑的体内扩散MRI:技术挑战和最新进展。
DOI:
10.1002/nbm.3941
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发表时间:
2019-04
影响因子:
2.9
通讯作者:
Aggarwal M
中科院分区:
文献类型:
--
作者:
Roebroeck A;Miller KL;Aggarwal M
This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on the human brain. We review the challenges posed by the properties of post‐mortem tissue, and discuss state‐of‐the‐art tissue preparation methods and recent advances in pulse sequences and acquisition techniques to tackle these. We then review recent ex vivo dMRI studies of the human brain, highlighting the validation of white matter orientation estimates and the atlasing and mapping of large subcortical structures. We also give particular emphasis to the delineation of layered gray matter structure with ex vivo dMRI, as this application illustrates the strength of its mesoscale resolution over large fields of view. We end with a discussion and outlook on future and potential directions of the field.
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Roebroeck A
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通讯作者:
Deisseroth, Karl