Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut-Liver Axis.
Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut-Liver Axis.
复制标题
多糖通过调节肠肝轴治疗非酒精性脂肪肝的研究进展。
DOI：
10.3390/ijms231911710
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发表时间：
2022-10-03
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
非酒精性脂肪性肝病(NAFLD)是目前影响全球公众健康的最常见的慢性肝病，严重时可诱发肝硬变和肝癌。然而，NAFLD是一种多因素疾病，其发病机制和治疗策略尚缺乏研究。随着肠肝轴理论的发展，肠肝轴与NAFLD发病机制的关系逐渐被揭示。多糖作为一种天然产物，具有低毒、多靶点、多途径作用等优点。已有研究表明，多糖可在多个相互关联的水平上影响肠道-肝轴，如维持肠道微生物区系的生态平衡，调节肠道微生物区系代谢产物，改善肠道屏障功能，从而对非酒精性脂肪性肝病起到保护作用。这些研究对于从肠-肝轴认识NAFLD，发展安全有效的药物治疗具有重要的科学意义。本文就近年来多糖通过肠道-肝轴改善非酒精性脂肪性肝病(NAFLD)的研究进展作一综述。
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting global public health at present, which can induce cirrhosis and liver cancer in serious cases. However, NAFLD is a multifactorial disease, and there is still a lack of research on its mechanism and therapeutic strategy. With the development of the gut–liver axis theory, the association between the gut–liver axis and the pathogenesis of NAFLD has been gradually disclosed. Polysaccharides, as a kind of natural product, have the advantages of low toxicity, multi-target and multi-pathway action. It has been reported that polysaccharides can affect the gut–liver axis at multiple interrelated levels, such as maintaining the ecological balance of gut microbiota (GM), regulating the metabolites of GM and improving the intestinal barrier function, which thereby plays a protective role in NAFLD. These studies have great scientific significance in understanding NAFLD based on the gut–liver axis and developing safe and effective medical treatments. Herein, we reviewed the recent progress of polysaccharides in improving nonalcoholic fatty liver disease (NAFLD) through the gut–liver axis.
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影响因子：
7.3
作者：
Beisner J;Filipe Rosa L;Kaden-Volynets V;Stolzer I;Günther C;Bischoff SC
通讯作者：
Bischoff SC
影响因子：
8.1
作者：
Ajmera V;Loomba R
通讯作者：
Loomba R
影响因子：
29
作者：
Clifford BL;Sedgeman LR;Williams KJ;Morand P;Cheng A;Jarrett KE;Chan AP;Brearley-Sholto MC;Wahlström A;Ashby JW;Barshop W;Wohlschlegel J;Calkin AC;Liu Y;Thorell A;Meikle PJ;Drew BG;Mack JJ;Marschall HU;Tarling EJ;Edwards PA;de Aguiar Vallim TQ
通讯作者：
de Aguiar Vallim TQ
影响因子：
7.7
作者：
den Besten, Gijs;Bleeker, Aycha;Bakker, Barbara M.
通讯作者：
Bakker, Barbara M.
影响因子：
3.5
作者：
Che, Jinying;Yang, Shuo;Wang, Chunmei
通讯作者：
Wang, Chunmei