Immunomodulatory drugs: oral and systemic adverse effects.
Immunomodulatory drugs: oral and systemic adverse effects.
复制标题
DOI：
10.4317/medoral.19087
复制
发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Meurman JH
中科院分区：
文献类型：
--
作者：
Bascones-Martinez A;Mattila R;Gomez-Font R;Meurman JH
目的：介绍影响免疫抑制患者生活质量的免疫调节药物的不同副作用，研究免疫调节对口腔疾病的影响。免疫调节药物已经改变了许多免疫功能发挥核心作用的疾病的治疗方案，例如风湿性疾病。然而，它们对口腔健康的影响还没有得到系统的研究。研究设计：基于开放式文献检索，我们从口腔健康的角度对目前有关新型免疫调节药物的数据进行综述。结果：与早期的免疫调节药物相比，这些靶向特定药物的药物相互作用似乎较少，但仍有潜在的副作用，如激活潜伏感染。有一些数据表明，新的免疫调节药物可能在治疗某些口腔疾病方面也有作用，如扁平苔藓或改善干燥S综合征的症状，但结果并不太乐观。结论：总的来说，关于这些新药对口腔疾病的影响的数据很少，而且还没有发表关于这一主题的适当有效的随机对照试验。关键词：免疫调节药物、口腔疾病、不良反应、治疗作用。
Objectives: The main objectives are to present the different adverses effects of the immunomodulatory drugs that can impair the quality of life of the immunosupressed patients and study the impact of immunomodualtion on oral diseases. Immunomodulatory drugs have changed the treatment protocols of many diseases where immune functions play a central role, such as rheumatic diseases. Their effect on oral health has not been systematically investigated, however. Study Design: We review current data on the new immunomodulatory drugs from the oral health perspective based on open literature search of the topic. Results: These target specific drugs appear to have less drug interactions than earlier immunomodulating medicines but have nevertheless potential side effects such as activating latent infections. There are some data showing that the new immunomodulatory drugs may also have a role in the treatment of certain oral diseases such as lichen planus or ameliorating symptoms in Sjögren´s syndrome, but the results have not been overly promising. Conclusions: In general, data are sparse of the effect of these new drugs vs. oral diseases and there are no properly powered randomized controlled trials published on this topic. Key words:Immunomodulatory drugs, oral diseases, adverse effects, therapeutic action.
登录
查看更多内容
影响因子：
5.5
作者：
Aringer, Martin;Houssiau, Frederic;Smole, Josef S.
通讯作者：
Smole, Josef S.
影响因子：
9.1
作者：
Chun, Hye-Young;Chung, Jae-Wook;Suh, Chang-Hee
通讯作者：
Suh, Chang-Hee
影响因子：
4.2
作者：
Gottenberg, J. -E.
通讯作者：
Gottenberg, J. -E.
影响因子：
14.2
作者：
Lee, Susan J.;Chinen, Javier;Kavanaugh, Arthur
通讯作者：
Kavanaugh, Arthur
影响因子：
--
作者：
Merrill, J. T.;Burgos-Vargas, R.;Nash, P.
通讯作者：
Nash, P.