Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry
Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry
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分化抗原可识别兔 T 和 B 淋巴细胞亚群。
DOI：
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发表时间：
1983
影响因子：
15.3
通讯作者：
T. Kindt
中科院分区：
文献类型：
--
作者：
S. Jackson;T. Chused;J. Wilkinson;W. Leiserson;T. Kindt
用流式细胞仪测定兔T淋巴细胞系细胞表面糖蛋白的6种单克隆抗体，确定兔淋巴细胞亚群。四个胸腺细胞群体的特征在于细胞表面抗原的大小和表达，并出现代表胸腺细胞分化的阶段。家兔脾脏含有5个亚群：2个T细胞亚群、2个B细胞亚群和1个空细胞亚群。在兔中使用针对Thy-1类似物的抗体（9AE 10）观察到胸腺细胞和外周T细胞染色的双峰分布，表明两种独立的T细胞谱系。双色免疫荧光显示，其中一种单克隆试剂L11/135与兔外周T细胞发生强烈反应。在功能研究中，只有L11/135轴承细胞的T细胞有丝分裂原伴刀豆球蛋白A和植物血凝素和同种异体脾细胞。胸腺细胞亚群和外周T和B细胞亚群与小鼠和人中描述的不同。
A panel of six monoclonal antibodies produced against cell surface glycoproteins of a rabbit T lymphocyte line was used with flow cytometry to define rabbit lymphocyte subpopulations. Four thymocyte populations were characterized by size and expression of cell surface antigens and appear to represent stages in thymocyte differentiation. Rabbit spleen contained five subpopulations: two of T lineage, two of B, and a null cell subset. Bimodal distribution of staining of thymocytes and peripheral T cells was observed using an antibody (9AE10) directed against a Thy-1 analogue in the rabbit, suggesting two separate T cell lineages. One of the monoclonal reagents, L11/135, reacted strongly with peripheral rabbit T cells as shown by two-color immunofluorescence. In functional studies, only the L11/135-bearing cells responded to the T cell mitogens concanavalin A and phytohemagglutinin and to allogeneic splenocytes. The thymocyte subpopulations and the peripheral T and B cell subsets differ from those described in mouse and man.
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影响因子：
4.4
作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
通讯作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
不同于 B1 的人类 B 细胞特异性抗原 (B2) 的表征。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Nadler,LM;Stashenko,P;Hardy,R;vanAgthoven,A;Terhorst,C;Schlossman,SF
通讯作者：
Schlossman,SF
DOI：
10.1073/pnas.79.14.4395
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEUER, SC;SCHLOSSMAN, SF;REINHERZ, EL
通讯作者：
REINHERZ, EL
兔淋巴细胞单克隆抗体：T 细胞特异性抗体的制备和表征。
影响因子：
3.6
作者：
McNicholas,JM;Raffeld,M;Loken,MR;Reiter,H;Knight,KL
通讯作者：
Knight,KL