Genetic instability occurs sooner than expected: promotion, progression and clonality during hepatocarcinogenesis in the rat.
Genetic instability occurs sooner than expected: promotion, progression and clonality during hepatocarcinogenesis in the rat.
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遗传不稳定性的发生比预期要早：大鼠肝癌发生过程中的促进、进展和克隆性。
DOI：
10.1007/978-1-4684-5994-4_23
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Abdul-Karim,F
中科院分区：
文献类型：
--
作者：
Sudilovsky,O;Hinrichsen,LI;Hei,TK;Whitacre,CM;Wang,JH;Kasturi,S;Jiang,SH;Cechner,R;Miron,S;Abdul-Karim,F
The basic question of “at which point in time does genetic instability occur in the natural history of cancer” can be answered only with another question: in which organ or model? Dr. Shapiro has just given us an impressive account of her work in human malignant gliomas. We also attempted to explore the problem but in a different organ, species and model system. We found that in the rat liver treated with diethylnitrosamine (DEN) and a choline deficient (CD) diet, genomic instability expressed by aneuploidy takes place during the promotion treatment, long before hepatocarcinomas can be diagnosed (1, 2). The presence of aneuploidy implies that irreversible genetic changes, characteristic of progression, occur during dietary promotion (Fig. 1). Since increasing evidence points out that most malignant hepatomas are monoclonal in origin, this fact and the studies previously mentioned have led us to propose now a scheme of cell renewal which explains the overlapping of promotion with progression arising in the clonally replicating foci of preneoplastic populations.
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大鼠肝癌模型中改变的肝病灶的核 DNA 含量。
影响因子：
11.2
作者：
Wang,JH;Hinrichsen,LI;Whitacre,CM;Cechner,RL;Sudilovsky,O
通讯作者：
Sudilovsky,O
预染色膜标记，以识别单个切片中用于福尔根细胞光度测定的特定区域。
DOI：
--
发表时间：
1987
期刊：
Analytical and quantitative cytology and histology
影响因子：
--
作者：
Sudilovsky,O;Hei,TK
通讯作者：
Hei,TK
肿瘤前和肿瘤性肝细胞中发生细胞死亡（细胞凋亡）。
DOI：
--
发表时间：
1984
期刊：
The American journal of pathology
影响因子：
--
作者：
Columbano,A;Ledda-Columbano,GM;Rao,PM;Rajalakshmi,S;Sarma,DS
通讯作者：
Sarma,DS
单个 GST-P 阳性肝细胞——推定的起始肝细胞。
影响因子：
4.7
作者：
M. Moore;K. Nakagawa;K. Satoh;T. Ishikawa;Kiyomi Sato
通讯作者：
Kiyomi Sato
癌前病变作为致癌性测试的终点。
影响因子：
4.7
作者：
P. Bannasch
通讯作者：
P. Bannasch