Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: Evidence from gene expression and behavior symptom analyses.
Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: Evidence from gene expression and behavior symptom analyses.
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与健康对照组相比，自闭症患者不同的功能连接最佳频率以及与社交沟通缺陷的关系：来自基因表达和行为症状分析的证据
DOI：
10.1002/hbm.26011
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发表时间：
2023-01
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
研究报告称，不同的大脑区域/连接具有不同的频率特性，这与大脑功能有关。先前的研究提出了自闭症谱系障碍(ASD)患者大脑活动频率和频率特异性功能连接(FC)模式的改变，这意味着在ASD中FC的主导频率不同。然而，ASD组和健康对照组(HCS)Fc主频的差异仍不清楚。在本研究中，用FC最佳频率来测量FC的主频，该频率定义为FC强度达到最大的频段的中间部分。多变量模式分析确定ASD患者和HCS患者的Fc最佳频率是否不同。通过偏最小二乘回归(PLSR)和富集化分析，确定ASD/HCS的Fc最佳频差与皮质基因表达的关系。PLSR分析还探讨了Fc最佳频率与ASD临床症状的关系。结果显示ASD组与HCS组的Fc最佳频率有显著差异。一些皮层表达模式与ASD/HCS的Fc最佳频差相关的基因因社交问题而被丰富。同时，ASD患者的Fc最佳频率与社交症状显著相关。这些结果可能有助于我们理解ASD社会沟通障碍的神经机制。研究表明，ASD患者某些静息状态FCS的最佳频率高于HCS患者。基因表达和临床症状证据表明，ASD/HCS的Fc最佳频率差异与ASD患者的社会沟通障碍有关。这些结果表明ASD的神经传递机制的主导频率特性发生了改变，这可能为ASD的行为症状，特别是社交障碍提供一个生物标志物。
Studies have reported that different brain regions/connections possess distinct frequency properties, which are related to brain function. Previous studies have proposed altered brain activity frequency and frequency‐specific functional connectivity (FC) patterns in autism spectrum disorder (ASD), implying the varied dominant frequency of FC in ASD. However, the difference of the dominant frequency of FC between ASD and healthy controls (HCs) remains unclear. In the present study, the dominant frequency of FC was measured by FC optimal frequency, which was defined as the intermediate of the frequency bin at which the FC strength could reach the maximum. A multivariate pattern analysis was conducted to determine whether the FC optimal frequency in ASD differs from that in HCs. Partial least squares regression (PLSR) and enrichment analyses were conducted to determine the relationship between the FC optimal frequency difference of ASD/HCs and cortical gene expression. PLSR analyses were also performed to explore the relationship between FC optimal frequency and the clinical symptoms of ASD. Results showed a significant difference of FC optimal frequency between ASD and HCs. Some genes whose cortical expression patterns are related to the FC optimal frequency difference of ASD/HCs were enriched for social communication problems. Meanwhile, the FC optimal frequency in ASD was significantly related to social communication symptoms. These results may help us understand the neuro‐mechanism of the social communication deficits in ASD. The study revealed that the optimal frequency of some resting‐state FCs in ASD was higher than that in HCs. The gene expression and clinical symptom evidence showed that the FC optimal frequency difference of ASD/HCs is related to social communication deficits in ASD. The results imply an altered dominant frequency property of the neural transmission mechanism in ASD, which may provide a biomarker for behavioral symptoms of ASD, particularly of social communication deficits.
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影响因子：
19.9
作者：
Herweg NA;Solomon EA;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
自闭症诊断观察表： 提高诊断有效性的修订算法
影响因子：
3.9
作者：
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1523/jneurosci.3554-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Alexander-Bloch A;Raznahan A;Bullmore E;Giedd J
通讯作者：
Giedd J
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.