Distinct neural generators of sensory gating in schizophrenia.
Distinct neural generators of sensory gating in schizophrenia.
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DOI：
10.1111/j.1469-8986.2010.01119.x
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发表时间：
2011-04
期刊：
影响因子：
3.7
通讯作者：
Yee CM
中科院分区：
文献类型：
--
作者：
Williams TJ;Nuechterlein KH;Subotnik KL;Yee CM
尽管抑制过程的故障被认为是精神分裂症的一种病理生理机制，并已通过P50门控范式进行了广泛的研究，但参与产生和抑制P50的大脑区域仍不清楚。本研究采用EEG源分析和标准S1-S2范式来阐明16例精神分裂症患者和14例健康受试者P50门控相关的神经结构。在已有研究的基础上，评估了颞上回、海马、背外侧前额叶皮层、丘脑及其偶极矩。在对P50进行建模时，一个涉及所有四个大脑区域的神经网络在两组之间提供了最佳的拟合优度。在健康受试者中，P50比值得分与海马偶极矩比值呈正相关，而在精神分裂症患者中，P50比值得分与DLPFC偶极矩比值显著相关。在每种情况下，神经结构都被发现在解释P50比率时具有独特的差异，并且在健康受试者中有一些DLPFC参与的暗示。
Although malfunctioning of inhibitory processes is proposed as a pathophysiological mechanism in schizophrenia and has been studied extensively with the P50 gating paradigm, the brain regions involved in generating and suppressing the P50 remain unclear. The current investigation used EEG source analysis and the standard S1-S2 paradigm to clarify the neural structures associated with P50 gating in16 schizophrenia patients and 14 healthy subjects. Based on prior research, the superior temporal gyrus, hippocampus, dorsolateral prefrontal cortex, thalamus, and their dipole moments were evaluated. In modeling the P50, a neural network involving all four brain regions provided the best goodness-of-fit across both groups. In healthy subjects, the P50 ratio score correlated positively with the hippocampal dipole moment ratio whereas a significant association with the DLPFC dipole moment ratio was observed in schizophrenia patients. In each instance, the neural structure was found to account for unique variance in explaining the P50 ratio, along with some suggestion of DLPFC involvement in healthy subjects.
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