Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants.
Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants.
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DOI：
10.3390/antibiotics12111563
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发表时间：
2023-10-25
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影响因子：
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In 2019, five million deaths associated with antimicrobial resistance were reported by The Centers for Disease Control and Prevention (CDC). Acinetobacter baumannii, a Gram-negative bacterial pathogen, is among the list of urgent threats. Previously, we reported 2-aminoimidazole (2-AI) adjuvants that potentiate macrolide activity against A. baumannii. In this study, we identify several of these adjuvants that sensitize A. baumannii to aminoglycoside antibiotics. Lead compounds 1 and 7 lower the tobramycin (TOB) minimum inhibitory concentration (MIC) against the TOB-resistant strain AB5075 from 128 μg/mL to 2 μg/mL at 30 μM. In addition, the lead compounds lower the TOB MIC against the TOB-susceptible strain AB19606 from 4 μg/mL to 1 μg/mL and 0.5 μg/mL, respectively, at 30 μM and 15 μM. The evolution of resistance to TOB and 1 in AB5075 revealed mutations in genes related to protein synthesis, the survival of bacteria under environmental stressors, bacteriophages, and proteins containing Ig-like domains.
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影响因子：
5
作者：
Milton, Morgan E.;Minrovic, Bradley M.;Cavanagh, John
通讯作者：
Cavanagh, John
DOI：
10.1073/pnas.2217254120
发表时间：
2023-03-21
影响因子：
11.1
作者：
Lv, Boyan;Huang, Xuebing;Lijia, Chenchen;Ma, Yuelong;Bian, Mengmeng;Li, Zhongyan;Duan, Juan;Zhou, Fang;Yang, Bin;Qie, Xingwang;Song, Yizhi;Wood, Thomas K.;Fu, Xinmiao
通讯作者：
Fu, Xinmiao
影响因子：
--
作者：
Klug DM;Idiris FIM;Blaskovich MAT;von Delft F;Dowson CG;Kirchhelle C;Roberts AP;Singer AC;Todd MH
通讯作者：
Todd MH
新的佐剂可以使大肠杆菌素对鲍曼尼菌的较低剂量。
影响因子：
5.3
作者：
Minrovic BM;Jung D;Melander RJ;Melander C
通讯作者：
Melander C
DOI：
10.1021/la504407v
发表时间：
2015
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Clifton LA;Skoda MW;Le Brun AP;Ciesielski F;Kuzmenko I;Holt SA;Lakey JH
通讯作者：
Lakey JH