Synthetic RNA switches as a tool for temporal and spatial control over gene expression.
Synthetic RNA switches as a tool for temporal and spatial control over gene expression.
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DOI：
10.1016/j.copbio.2012.01.005
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发表时间：
2012-10
影响因子：
7.7
通讯作者：
Smolke, Christina D.
中科院分区：
文献类型：
--
作者：
Chang, Andrew L.;Wolf, Joshua J.;Smolke, Christina D.
生物系统工程为健康和医学、化学合成、能源生产和环境可持续性等领域的进步提供了重要的希望。实现这一潜力需要能够设计复杂遗传系统的工具。RNA的功能多样性使其成为编程传感，信息处理，计算和控制功能的有吸引力和多功能的底物。能够检测和响应分子和环境信号的合成RNA开关设计的最新进展使得能够通过多种机制动态调节基因表达，包括转录、剪接、稳定性、RNA干扰和翻译。此外，在遗传电路中实现这些开关突出了构建针对环境修复和下一代治疗和诊断应用的合成细胞系统的潜力。
The engineering of biological systems offers significant promise for advances in areas including health and medicine, chemical synthesis, energy production, and environmental sustainability. Realizing this potential requires tools that enable design of sophisticated genetic systems. The functional diversity of RNA makes it an attractive and versatile substrate for programming sensing, information processing, computation, and control functions. Recent advances in the design of synthetic RNA switches capable of detecting and responding to molecular and environmental signals enable dynamic modulation of gene expression through diverse mechanisms, including transcription, splicing, stability, RNA interference, and translation. Furthermore, implementation of these switches in genetic circuits highlights the potential for building synthetic cell systems targeted to applications in environmental remediation and next-generation therapeutics and diagnostics.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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