Low rates of hepatitis A and B vaccination in patients with chronic hepatitis C at an urban methadone maintenance program.
Low rates of hepatitis A and B vaccination in patients with chronic hepatitis C at an urban methadone maintenance program.
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DOI：
10.1080/10550887.2010.509281
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发表时间：
2010-10
影响因子：
2.3
通讯作者：
Litwin AH
中科院分区：
文献类型：
--
作者：
Felsen UR;Fishbein DA;Litwin AH
慢性丙型肝炎病毒（HCV）患者如果感染甲型肝炎（HAV）或B肝炎（HBV）病毒，则其肝病并发症的风险增加。所有管理慢性HCV患者的主要指南都包括为尚未免疫的患者接种HAV和HBV疫苗的建议。我们检查了接受美沙酮维持计划（MMP）的慢性HCV感染患者的HAV、HBV和HCV检测率，以及HAV和HBV疫苗接种率。回顾性审查随机样本（n=207）的医疗记录的患者参加了学术附属，城市MMP提供现场初级保健服务。慢性HCV患者的HAV、HBV和HCV血清状态以及HAV和HBV疫苗接种率。几乎所有的患者都接受了HAV，HBV和HCV的检测。在111例慢性HCV感染者中，53例（48.6%）HAV和68例（63%）HBV免疫力低下。在免疫力低下者中，分别有29人（54.7%）和2人（2.9%）接种了甲型肝炎疫苗和乙型肝炎疫苗。尽管在城市美沙酮维持计划中HAV，HBV和HCV的检测率很高，但约有一半符合HAV疫苗的慢性HCV患者接受了HAV疫苗，而符合HBV疫苗的患者很少接受HAV疫苗。
Patients with chronic hepatitis C virus (HCV) are at increased risk for complications of liver disease if they become infected with the hepatitis A (HAV) or hepatitis B (HBV) viruses. All major guidelines for the management of patients with chronic HCV include the recommendation for vaccination against HAV and HBV for those who are not already immune. We examined the rates of testing for HAV, HBV, and HCV, as well as rates of vaccination against HAV and HBV in patients with chronic HCV infection at a methadone maintenance program (MMP). Retrospective review of a random sample (n=207) of medical records of patients enrolled in an academically affiliated, urban MMP providing on-site primary care services. Serostatus for HAV, HBV, and HCV and rates of vaccination for HAV and HBV in those patients with chronic HCV. Almost all patients reviewed were tested for HAV, HBV, and HCV. Of the 111 patients found to be chronically infected with HCV, 53 (48.6%) and 68 (63%) were found to lack immunity to HAV and HBV respectively. Of those lacking immunity, 29 (54.7%) and 2 (2.9%) were then vaccinated for HAV and HBV respectively. Despite high rates of testing for HAV, HBV, and HCV at an urban methadone maintenance program, approximately half of those with chronic HCV eligible for the HAV vaccine received it and very few of those eligible for HBV vaccine received it.
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