Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis.
Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis.
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DOI：
10.3390/ijms21197336
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发表时间：
2020-10-04
影响因子：
5.6
通讯作者：
Mandolesi G
中科院分区：
文献类型：
--
作者：
Dolcetti E;Bruno A;Guadalupi L;Rizzo FR;Musella A;Gentile A;De Vito F;Caioli S;Bullitta S;Fresegna D;Vanni V;Balletta S;Sanna K;Buttari F;Stampanoni Bassi M;Centonze D;Mandolesi G
细胞外囊泡（EV）作为细胞间通讯的替代模式，代表了许多生理和病理功能的新现实。这是由于它们与远处受体细胞相互作用的能力，通常涉及将EV内容物递送到靶细胞中。深入的研究针对EV在不同病理条件下的作用，包括多发性硬化症（MS）。MS是神经系统的慢性炎症性和神经退行性疾病，是年轻人神经功能障碍的主要原因之一。免疫系统和神经系统之间的相互作用在这种疾病中发生了深刻的改变，EV似乎对MS发病机制有相关影响。在这里，我们提供了一个概述的临床和临床前研究表明，从血脑屏障（BBB）内皮细胞，血小板，白细胞，骨髓细胞，星形胶质细胞和少突胶质细胞释放的EV参与MS及其啮齿动物模型实验性自身免疫性脑脊髓炎（EAE）的发病机制。大多数信息指出EV对BBB损伤、传播促炎信号和改变神经元功能的影响，但EV对脑损伤的修复功能值得关注。最后，我们将描述关于EV作为MS治疗干预的潜在治疗靶点和工具的最新进展。
Extracellular vesicles (EVs) represent a new reality for many physiological and pathological functions as an alternative mode of intercellular communication. This is due to their capacity to interact with distant recipient cells, usually involving delivery of the EVs contents into the target cells. Intensive investigation has targeted the role of EVs in different pathological conditions, including multiple sclerosis (MS). MS is a chronic inflammatory and neurodegenerative disease of the nervous system, one of the main causes of neurological disability in young adults. The fine interplay between the immune and nervous systems is profoundly altered in this disease, and EVs seems to have a relevant impact on MS pathogenesis. Here, we provide an overview of both clinical and preclinical studies showing that EVs released from blood–brain barrier (BBB) endothelial cells, platelets, leukocytes, myeloid cells, astrocytes, and oligodendrocytes are involved in the pathogenesis of MS and of its rodent model experimental autoimmune encephalomyelitis (EAE). Most of the information points to an impact of EVs on BBB damage, on spreading pro-inflammatory signals, and altering neuronal functions, but EVs reparative function of brain damage deserves attention. Finally, we will describe recent advances about EVs as potential therapeutic targets and tools for therapeutic intervention in MS.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
7.7
作者：
Gabrielli, Martina;Battista, Natalia;Verderio, Claudia
通讯作者：
Verderio, Claudia
影响因子：
3.4
作者：
Carandini T;Colombo F;Finardi A;Casella G;Garzetti L;Verderio C;Furlan R
通讯作者：
Furlan R
影响因子：
5.3
作者：
Brites D;Fernandes A
通讯作者：
Fernandes A
影响因子：
5.3
作者：
Geraci F;Ragonese P;Barreca MM;Aliotta E;Mazzola MA;Realmuto S;Vazzoler G;Savettieri G;Sconzo G;Salemi G
通讯作者：
Salemi G