Skeletal changes following growth hormone treatment in a child with combined hypopituitarism and a skeletal dysplasia.
Skeletal changes following growth hormone treatment in a child with combined hypopituitarism and a skeletal dysplasia.
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患有垂体功能低下和骨骼发育不良的儿童接受生长激素治疗后骨骼发生变化。
DOI：
10.1530/acta.0.1030302
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Grunt
中科院分区：
文献类型：
--
作者：
W. Horton;C. Howard;J. Grunt
一个孩子结合垂体功能减退症和一个不明确的骨骼发育不良的描述。垂体功能减退症表现为出生后生长障碍、皮下脂肪过多、小阴茎和对刺激试验的生长激素反应差。不对称短肢，尤其是远端，骨骼X线片显示全身性短指、趾骨锥形骨骺和股骨近端干骺端骨化缺损，是骨骼发育不良的特征。与垂体功能减退症中所见的软骨内生长板的正常结构相反，该儿童的生长板结构异常;软骨细胞未分化为肥大和退行性细胞。用hGH处理8个月与软骨细胞分化的出现、生长板结构恢复到几乎正常和生长速率的大幅增加相关。他的比例不称没有改变，放射学异常也没有改善。这些观察结果表明，在某些情况下，hGH可能会影响生长板结构，这可能与线性生长增加有关。
A child with combined hypopituitarism and an undefined skeletal dysplasia is described. The hypopituitarism was manifested by post-natal growth failure, excessive sc fat, micropenis, and poor growth hormone response to provocative tests. Disproportionately short limbs, especially distally, and skeletal radiographs showing generalized brachydactyly, cone epiphyses of the phalanges and ossification defects in the proximal femoral metaphyses characterized the skeletal dysplasia. In contrast to the normal structure of the endochondral growth plate seen in hypopituitarism, the growth plate in this child was structurally abnormal; there was no differentiation of chondrocytes into hypertrophic and degenerative cells. Treatment with hGH for 8 months was associated with the appearance of chondrocyte differentiation, the restoration of growth plate structure to almost normal and a substantial increase in growth rate. There was no change in his disproportion or improvement in his radiographic abnormalities. These observations suggest that hGH may influence growth plate structure in certain instances and that this may be associated with increased linear growth.
自体生长因子在培养的胎鼠颅骨中刺激 DNA 和胶原蛋白的合成。
DOI：
10.1126/science.7434011
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Canalis,E;Peck,WA;Raisz,LG
通讯作者：
Raisz,LG