The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells.
The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells.
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结核分枝杆菌早期分泌的6 kDa抗原靶点对KSHV感染细胞的潜在影响
DOI：
10.1002/jmv.26291
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发表时间：
2021-06
影响因子：
12.7
通讯作者：
Qin Z
中科院分区：
文献类型：
--
作者：
Dai L;Jung BG;Chen J;Samten B;Forrest JC;Post SR;Qin Z
卡波西肉瘤相关疱疹病毒(KSHV)导致几种人类癌症，包括卡波西肉瘤(KS)和原发性渗出性淋巴瘤(PEL)，这些疾病大多见于免疫功能低下的患者，如HIV+患者。由细菌病原体结核分枝杆菌(Mtb)引起的结核病(TB)仍然是世界上致死率最高的传染病之一。艾滋病毒携带者患结核病的风险比未感染艾滋病毒的人高得多。病例报告将HIV+患者的皮肤或肺KS与分枝杆菌合并感染联系在一起，然而，Mtb感染或其产物对KSHV感染细胞的影响尚不清楚。我们在这里报道，ESAT-6，一种分泌的Mtb毒力因子，诱导KSHV感染细胞的病毒重新激活。KSHV感染的肺内皮细胞对ESAT-6诱导的细胞生长抑制有抵抗作用。我们的数据表明，结核分枝杆菌毒力因子影响KSHV感染细胞的生物学，突出了研究这两种病原体之间相互作用的必要性，这两种病原体通常在艾滋病毒携带者中发现。
Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human cancers, including Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), which are mostly seen in immunocompromised patients such as HIV+ individuals. Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb), remains one of the deadliest infectious diseases in the world. The risk of developing TB is dramatically higher in people living with HIV than among those without HIV infection. Case reports link cutaneous or pulmonary KS in HIV+ patients with mycobacterial co-infections, however, impacts of Mtb infection or its products on KSHV-infected cells are not known. We report here that ESAT-6, a secreted Mtb virulence factor, induces viral reactivation from KSHV-infected cells. KSHV-infected pulmonary endothelial cells were resistant to ESAT-6 induced inhibition of cell growth. Our data demonstrate that Mtb virulence factors influence the biology of KSHV-infected cells, highlighting the need to study the interactions between these two pathogens commonly found in people living with HIV.
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影响因子：
30.3
作者：
Srivastava S;Ernst JD
通讯作者：
Ernst JD
影响因子：
4.8
作者：
Boggaram, Vijay;Gottipati, Koteswara R.;Samten, Buka
通讯作者：
Samten, Buka
影响因子：
20.3
作者：
Oksenhendler, Eric;Boutboul, David;Galicier, Lionel
通讯作者：
Galicier, Lionel
影响因子：
39.2
作者：
SAFAI, B;JOHNSON, KG;DUPONT, B
通讯作者：
DUPONT, B
影响因子：
3
作者：
Palmieri, C.;Dhillon, T.;Bower, M.
通讯作者：
Bower, M.