Correlations between 13 Trace Elements and Circulating Tumor Cells in Patients with Colorectal Cancer in Guangzhou, China
Correlations between 13 Trace Elements and Circulating Tumor Cells in Patients with Colorectal Cancer in Guangzhou, China
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中国广州地区结直肠癌患者13种微量元素与循环肿瘤细胞的相关性
DOI：
10.1007/s12011-020-02061-7
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发表时间：
2020-02
影响因子：
3.9
通讯作者：
Shen Mei
中科院分区：
文献类型：
--
作者：
Wang Hetao;Liu Hao;Zhou Meijuan;Shi Hanping;Shen Mei
建立了测定全血中13种微量元素(TES)的方法，测定了结直肠癌(CRC)患者的TES水平，并探讨了TES与循环肿瘤细胞(CTCs)的相关性。纳入广州地区93例结直肠癌患者和48例正常对照中国。采用电感耦合等离子体质谱(ICPMS)检测13例TES患者的血药浓度。应用CanPatrol™对13例结直肠癌患者的CTCs进行了检测。结直肠癌患者血清镁、铁、锌、硒、锶、钼、钡均低于正常对照组(P<； )。血清镁、铁、锌、硒、钡含量随TNM分期的增加而降低。早期结直肠癌患者锌、硒降低程度高于晚期结直肠癌患者。结直肠癌患者血清铜、镍水平均高于正常对照组(P<； 均为0.05)。早期结直肠癌患者血清铜水平随TNM分期升高而升高，而镍水平高于晚期结直肠癌患者。因此，结直肠癌患者的TE水平随着TNM分期的不同而有差异。上皮性CTCs(E-CTCs)、间质性CTCs(M-CTCs)与CTCs的数量呈正相关(P<； )。血清中镁、铬、铁、铜、锌、硒、锶、钡等元素含量与CTCs数呈正相关(P<； )。全血中特异的TE模式有助于结直肠癌的早期诊断。TE水平和CTC的联合测定可能有助于分期和指导治疗。
We established a method of determining 13 trace elements (TEs) in whole blood, determined the levels of the TEs in patients with colorectal cancer (CRC), and examined the correlations between the TEs and circulating tumor cells (CTCs). A total of 93 CRC patients and 48 control subjects in Guangzhou, China, were included. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure the blood levels of 13 TEs. CTCs of 13 CRC patients were examined using CanPatrol™. The levels of Mg, Fe, Zn, Se, Sr, Mo, and Ba in CRC patients were lower than those in control subjects (all,P< 0.05). The levels of Mg, Fe, Zn, Se, and Ba decreased with increasing TNM stage. The reductions of Zn and Se levels were higher in early-stage than late-stage CRC patients. The levels of Cu and Ni were higher in CRC patients than in control subjects (both,P< 0.05). The Cu level increased with increased TNM stage, and Ni level was higher in early-stage CRC patients as compared with late-stage CRC patients. Consequently, the TE levels showed differences as the process of TNM stage of CRC patients. There were correlations between the amount of CTCs and epithelial-CTCs (E-CTCs) and interstitial-CTCs (M-CTCs) (P< 0.05). The levels of Mg, Cr, Fe, Cu, Zn, Se, Sr, and Ba were correlated with the number of CTCs (P< 0.05). Specific TE patterns in whole blood may assist in the early diagnosis of CRC. The combined determination of TE levels and CTCs may be useful as an adjunct to staging and guiding treatments.
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影响因子：
3.7
作者：
Wu S;Liu S;Liu Z;Huang J;Pu X;Li J;Yang D;Deng H;Yang N;Xu J
通讯作者：
Xu J
影响因子：
5.6
作者：
Chen CJ;Sung WW;Chen HC;Chern YJ;Hsu HT;Lin YM;Lin SH;Peck K;Yeh KT
通讯作者：
Yeh KT
DOI：
10.1016/b978-1-4160-3251-9.50008-x
发表时间：
2019-10
期刊：
The Lancet
影响因子：
--
作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
通讯作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
168.9
作者：
Midgley, R;Kerr, D
通讯作者：
Kerr, D