Adoption of Serogroup B Meningococcal Vaccine Recommendations.

Adoption of Serogroup B Meningococcal Vaccine Recommendations.
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DOI:
10.1542/peds.2018-0344
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发表时间:
2018-09
期刊:
影响因子:
8
通讯作者:
Albert AP
Albert AP
中科院分区:
医学2区
文献类型:
--
作者:
Kempe A;Allison MA;MacNeil JR;O'Leary ST;Crane LA;Beaty BL;Hurley LP;Brtnikova M;Lindley MC;Albert AP

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2015年,ACIP建议16-23奥尔兹可以根据个人临床决策接种血清群B脑膜炎球菌(MenB)疫苗(B类)。在美国儿科医生(Peds)和家庭医生(FPs)中评估:1)关于MenB疫苗接种的实践; 2)影响推荐疫苗决定的因素; 3)与16-18岁常规访视时讨论MenB疫苗相关的因素。我们从2016年10月至12月通过电子邮件和互联网调查了具有全国代表性的儿科和FP样本。有效率为72%(660/916)。在常规访视期间,51%的儿科和31%的FP报告总是/经常讨论MenB疫苗。在经常/总是讨论的人中,91%的人建议接种疫苗;在从不/很少讨论的人中,11%的人建议接种疫苗。73%的儿科和41%的FP目前接种了MenB疫苗。虽然许多提供者报告不知道影响推荐决定的因素,但血清型B脑膜炎球菌病爆发(89%),疾病发病率(62%)和有效性(52%),安全性(48%)和MenB疫苗的保护期(39%)增加了推荐的可能性,而类别B建议(45%)降低了可能性。那些稍微/完全不知道MenB疫苗的人[风险比0.32(95% CI 0.25-0.41)]和那些在HMO工作的人[0.39(0.18-0.87)]的可能性较小,而那些知道他们所在州疾病爆发的人[1.25(1.08-1.45)]更有可能开始讨论MenB疫苗。初级保健医生在关于血清群B脑膜炎球菌病和MenB疫苗的知识方面存在重大差距,这似乎是决定不讨论疫苗的主要驱动因素。
In 2015, ACIP recommended 16–23 year olds may be vaccinated with serogroup B meningococcal (MenB) vaccine based on individual clinical decision-making (Category B). To assess among US pediatricians (Peds) and family physicians (FPs): 1) practices regarding MenB vaccine delivery; 2) factors influencing a decision to recommend vaccine; 3) factors associated with discussing MenB vaccine at 16–18 year-old routine visits. We surveyed a nationally representative sample of Peds and FPs by e-mail and internet from 10–12/2016. The response rate was 72% (660/916). During routine visits, 51% of Peds and 31% of FPs reported always/often discussing MenB vaccine. Among those who discussed often/always, 91% recommended vaccination; among those who never/rarely discussed, 11% recommended. 73% of Peds and 41% of FPs currently administered MenB vaccine. While many providers reported not knowing about factors influencing recommendation decisions, serogroup B meningococcal disease outbreaks (89%), disease incidence (62%), and effectiveness (52%), safety (48%), and duration of protection of MenB vaccine (39%) increased likelihood of recommending while the Category B recommendation (45%) decreased likelihood. Those somewhat/not at all aware of MenB vaccine [Risk Ratio 0.32 (95% CI 0.25–0.41)] and those practicing in an HMO [0.39 (0.18–0.87)] were less likely whereas those aware of disease outbreaks in their state [1.25 (1.08–1.45)] were more likely to initiate a discussion about MenB vaccine. Primary care physicians have significant gaps in knowledge about serogroup B meningococcal disease and MenB vaccine and this appears to be a major driver of the decision not to discuss the vaccines.
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