Interplay of magnetic interactions and active movements in the formation of magnetosome chains.
Interplay of magnetic interactions and active movements in the formation of magnetosome chains.
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DOI：
10.1371/journal.pone.0033562
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Faivre D
中科院分区：
文献类型：
--
作者：
Klumpp S;Faivre D
趋磁细菌组装磁小体链，磁小体是含有磁性纳米晶体的细胞器。近年来，已经确定了这些晶体的受控生物矿化和磁小体链组装中涉及的一些遗传因素，但具体的生物调节如何与一般的物理过程（如扩散和磁相互作用）协调仍然没有解决。在这里，这些问题通过模拟磁小体链形成的不同场景来解决，其中各种物理过程和相互作用要么打开要么关闭。模拟结果表明，磁小体扩散的纯物理过程，由它们的磁相互作用的指导下，是不够的实验观察到的强大的链形成，并建议磁小体的生物编码的主动运动可能是必需的。毫不奇怪，当磁性相互作用和主动运动协调时，链模式最接近实验结果。我们估计，这种主动运输所产生的力与细胞骨架丝的聚合或解聚所产生的力是相容的。模拟结果表明，mamK缺失菌株的多效性表型可能是由于磁小体的主动运动缺陷，磁小体囊泡中的晶体形成与M. gryphiswaldense，而M.磁性物质
Magnetotactic bacteria assemble chains of magnetosomes, organelles that contain magnetic nano-crystals. A number of genetic factors involved in the controlled biomineralization of these crystals and the assembly of magnetosome chains have been identified in recent years, but how the specific biological regulation is coordinated with general physical processes such as diffusion and magnetic interactions remains unresolved. Here, these questions are addressed by simulations of different scenarios for magnetosome chain formation, in which various physical processes and interactions are either switched on or off. The simulation results indicate that purely physical processes of magnetosome diffusion, guided by their magnetic interactions, are not sufficient for the robust chain formation observed experimentally and suggest that biologically encoded active movements of magnetosomes may be required. Not surprisingly, the chain pattern is most resembling experimental results when both magnetic interactions and active movement are coordinated. We estimate that the force such active transport has to generate is compatible with forces generated by the polymerization or depolymerization of cytoskeletal filaments. The simulations suggest that the pleiotropic phenotypes of mamK deletion strains may be due to a defect in active motility of magnetosomes and that crystal formation in magneteosome vesicles is coupled to the activation of their active motility in M. gryphiswaldense, but not in M. magneticum.
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影响因子：
56.9
作者：
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通讯作者：
Xie, X. Sunney
影响因子：
56.9
作者：
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通讯作者：
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影响因子：
3.2
作者：
Ding, Yao;Li, Jinhua;Li, Jilun
通讯作者：
Li, Jilun
影响因子：
3.2
作者：
Elowitz, MB;Surette, MG;Leibler, S
通讯作者：
Leibler, S