Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy.
Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy.
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DOI：
10.3390/biomedicines10030557
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发表时间：
2022-02-26
期刊：
影响因子：
4.7
通讯作者：
Kidane D
中科院分区：
文献类型：
--
作者：
Zhao S;Habib SL;Senejani AG;Sebastian M;Kidane D
先天免疫对于立即识别和消除入侵病原体或防御癌细胞生长至关重要。先天免疫系统的失调与不同类型的炎性疾病（包括癌症）的发病机制相关。此外，维持先天免疫细胞的基因组完整性对所有生物体的生存至关重要。先天免疫细胞产生的氧化应激可能会导致自身造成的DNA碱基损伤以及对其他邻近细胞（包括癌细胞）的DNA损伤。氧化性DNA碱基损伤主要通过碱基切除修复（BER）来修复。BER处理癌症和先天免疫细胞中存在的不同类型的DNA碱基损伤，以保持基因组的完整性。然而，BER基因的突变导致DNA修复功能受损，导致基因组完整性不足。此外，一些研究表明，DNA损伤的积累导致染色体不稳定，可能激活先天免疫信号。此外，癌细胞中BER因子的失调调节先天免疫细胞向肿瘤微环境的浸润。在目前的综述中，BER在癌症和先天免疫细胞中的作用及其对肿瘤微环境中先天免疫信号传导的影响进行了总结。这是一个特别的问题，重点是DNA损伤和癌症治疗，以证明BER抑制剂或异常修复如何调节先天性炎症反应和影响免疫治疗方法。总体而言，审查提供了大量的证据，以了解BER在先天免疫反应动力学的影响，在目前的免疫为基础的治疗策略。
Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases, including cancer. In addition, the maintenance of innate immune cells’ genomic integrity is crucial for the survival of all organisms. Oxidative stress generated from innate immune cells may cause self-inflicted DNA base lesions as well as DNA damage on others neighboring cells, including cancer cells. Oxidative DNA base damage is predominantly repaired by base excision repair (BER). BER process different types of DNA base lesions that are presented in cancer and innate immune cells to maintain genomic integrity. However, mutations in BER genes lead to impaired DNA repair function and cause insufficient genomic integrity. Moreover, several studies have implicated that accumulation of DNA damage leads to chromosomal instability that likely activates the innate immune signaling. Furthermore, dysregulation of BER factors in cancer cells modulate the infiltration of innate immune cells to the tumor microenvironment. In the current review, the role of BER in cancer and innate immune cells and its impact on innate immune signaling within the tumor microenvironment is summarized. This is a special issue that focuses on DNA damage and cancer therapy to demonstrate how BER inhibitor or aberrant repair modulates innate inflammatory response and impact immunotherapy approaches. Overall, the review provides substantial evidence to understand the impact of BER in innate immune response dynamics within the current immune-based therapeutic strategy.
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由8-氧气的DNA糖基酶-1-kRAS-NF-κB途径引起的先天炎症。
DOI：
10.4049/jimmunol.1401625
发表时间：
2014-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Aguilera-Aguirre L;Bacsi A;Radak Z;Hazra TK;Mitra S;Sur S;Brasier AR;Ba X;Boldogh I
通讯作者：
Boldogh I
染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
人胃癌相关的DNA聚合酶β变异D160N是一种诱导细胞转化的突变器。
影响因子：
3.8
作者：
Donigan, Katherine A.;Hile, Suzanne E.;Eckert, Kristin A.;Sweasy, Joann B.
通讯作者：
Sweasy, Joann B.
影响因子：
3.7
作者：
Azzam G;Wang X;Bell D;Murphy ME
通讯作者：
Murphy ME
DOI：
10.1038/nri3921
发表时间：
2015-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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