Platelet serotonin content and plasma tryptophan in peri‐ and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms
Platelet serotonin content and plasma tryptophan in peri‐ and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms
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围绝经期和绝经后妇女的血小板血清素含量和血浆色氨酸：血浆雌激素水平和抑郁症状的变化
DOI：
10.1111/j.1365-2362.1988.tb01262.x
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发表时间：
1988
影响因子：
5.5
通讯作者：
P. Meyer
中科院分区：
文献类型：
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作者：
P. Guicheney;D. Léger;J. Barrat;R. Trevoux;B. Lignières;P. Roques;J. Garnier;P. Boyer;J. Grenier;C. Dreux;P. Meyer
抽象的。采用高压液相色谱法测定了56例绝经期和绝经后妇女的血小板5-羟色胺含量，以研究该参数随激素水平和抑郁情绪症状的变化。临床症状通过自我报告抑郁症状量表（NIMH的CES-D）进行评估。38名得分为16分或以上的女性被认为存在抑郁症状（平均得分± SD = 28.8 ± 10.5），而其他女性则构成对照组（n= 18，得分= 4.4 ± 4.2）。“抑郁”组的血小板5-羟色胺含量显著较低（0·302 ± 0·010 vs. 0·366 ± 0·020 nmol 10 - 8血小板，x ± s + SEM，P< 0·001，Mann-Whitney U-检验）。在曾接受过一次或多次抑郁发作治疗的“抑郁”女性中，血小板5-HT含量（0.283 ± 0.023，n= 18，P<0.01）显著低于对照组。在既往无抑郁发作的患者中，nmol 10 - 8血小板中表达的5-羟色胺与对照组无显著差异，但血液中表达的5-羟色胺略低于对照组（0·890 ± 0·085，n= 20 vs. 1·088 ± 0·090 nmol ml-1，n= 18，P<0·02）。血小板5-羟色胺含量呈正相关，血浆雌酮和雌二醇浓度之间的控制组，但不是在“抑郁”组。在血浆雌二醇< 50 ng l-1的女性中，黄体生成素和FSH测定显示“抑郁"女性的LH值低于”非抑郁“女性（19.6 ± 2.2，n= 23 vs. 26.1 ± 1.9 mIU ml-1，n= 9，x ± SEM，P<0.01）。血小板5-HT含量的变化似乎并不继发于血浆游离色氨酸和总色氨酸的变化，因为在抑郁症状或血浆雌激素浓度中均未检测到这些参数的变化。
Abstract. Platelet serotonin content was measured by high pressure liquid chromatography in 56 peri and postmenopausal women, in order to study variations of this parameter with hormonal status and depressive mood symptoms. Clinical symptoms were assessed by a self‐report depression symptom scale (CES‐D of NIMH). Thirty‐eight women with a score of 16 or more were considered as presenting depressive symptoms (mean score ± SD = 28·8 ± 10·5), while the others formed the control group (n= 18, score = 4·4 ± 4·2). Platelet serotonin contents were significantly lower in the ‘depressed’ group (0·302 ± 0·010 vs. 0·366 ± 0·020 nmol 10‐8 platelets, x̄+ SEM, P< 0·001 by Mann‐Whitney U‐test). In ‘depressed’ women who had been treated for one or more depressive episodes, platelet 5‐HT contents (0·283 ± 0·023, n= 18, P<0·01) were significantly lower with respect to controls. In patients without previous episodes of depression, serotonin expressed in nmol 10‐8 platelets did not differ significantly from controls but serotonin expressed in nmol ml‐1 of blood was slightly lower than control values (0·890 ± 0·085, n= 20 vs. 1·088 ± 0·090 nmol ml‐1, n= 18, P<0·02). Platelet serotonin content was positively correlated to plasma oestrone and oestradiol concentrations among the control group but not in the ‘depressed’ group. Luteinizing hormone and FSH determination in women with plasma oestradiol < 50 ng l‐1 showed lower LH values in ‘depressed’ than in ‘non‐depressed’ women (19·6 ± 2·2, n= 23 vs. 26·1 ± 1·9 mIU ml‐1, n= 9, x̄± SEM, P<0·01). Variations in platelet 5‐HT content did not appear to be secondary to alteration of plasma‐free and total tryptophan since no modifications of these parameters were detected either with depressive symptoms or with plasma oestrogen concentrations.
影响因子：
--
作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
通讯作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
有证据表明去甲肾上腺素和肾上腺素系统介导卵巢激素对黄体生成素和黄体生成素释放激素的刺激作用。
影响因子：
4.8
作者：
Adler,BA;Johnson,MD;Lynch,CO;Crowley,WR
通讯作者：
Crowley,WR