Oxytocin mediates the acquisition of filial, odor-guided huddling for maternally-associated odor in preweanling rats.
Oxytocin mediates the acquisition of filial, odor-guided huddling for maternally-associated odor in preweanling rats.
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DOI：
10.1016/j.yhbeh.2011.08.003
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发表时间：
2011-11
影响因子：
3.5
通讯作者：
Alberts, Jeffrey R.
中科院分区：
文献类型：
--
作者：
Kojima, Sayuri;Alberts, Jeffrey R.
关键词：
The present study was designed to examine possible roles of oxytocin (OT) in the acquisition of a filial huddling preference in preweanling rats. We used a procedure in which a scented, foster mother can induce an odor-guided huddling preference in preweanling pups, following a single, 2-h-long co-habitation. This single, discrete period for preference learning enables us to observe the mother-pup interactions that establish the pups’ preferences and to intervene with experimental manipulations. Four, 14-day-old littermates interacted with a scented foster mother that provided maternal care during a 2-h session. Two of the pups were pretreated with an intracerebroventricular injection of OT or an oxytocin antagonist (OTA), and the others received a vehicle injection. Filial preference for a maternally-paired odor was measured in a huddling test the next day. OT is necessary for acquisition of the filial preference: Odor learning was blocked in the pups treated with OTA, but not in their vehicle-treated littermates who experienced the same mother at the same time. Injection with exogenous OT did not augment the pups’ preference. Manipulating pups’ central OT also altered the contact interactions of the mother and pups. When some pups received OT, mother-litter aggregations formed as frequently and with similar combinations of bodies, but contact aggregations were significantly more cohesive than when some pups in the litter received OTA. We discuss dual, behavioral and neuroendocrine roles of OT in social learning by preweanling rats.
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