Multivariate meta-analysis for non-linear and other multi-parameter associations.

Multivariate meta-analysis for non-linear and other multi-parameter associations.
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DOI:
10.1002/sim.5471
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发表时间:
2012-12-20
影响因子:
2
通讯作者:
Kenward, M. G.
Kenward, M. G.
中科院分区:
医学3区
文献类型:
--
作者:
Gasparrini, A.;Armstrong, B.;Kenward, M. G.

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在本文中,我们正式应用多元荟萃分析和荟萃回归综合估计的多参数协会从不同的研究。这种建模方法扩展了用于联合收割机将不同亚组或人群的结果合并的标准两阶段分析。最直接的应用是非线性关系的元分析,例如通过样条或其他函数的回归系数来描述,但该方法很容易推广到任何设置,其中复杂的关联由多个相关参数来描述。多元荟萃分析的建模框架在统计环境R中的mvmeta包中实现。作为一个说明性的例子,我们提出了一个两阶段的分析,调查温度和非意外死亡率之间的非线性关系,使用时间序列数据从多个城市。多元荟萃分析是一个有用的分析工具,通过两个阶段的程序研究复杂的协会。版权所有© 2012约翰威利父子有限公司.
In this paper, we formalize the application of multivariate meta-analysis and meta-regression to synthesize estimates of multi-parameter associations obtained from different studies. This modelling approach extends the standard two-stage analysis used to combine results across different sub-groups or populations. The most straightforward application is for the meta-analysis of non-linear relationships, described for example by regression coefficients of splines or other functions, but the methodology easily generalizes to any setting where complex associations are described by multiple correlated parameters. The modelling framework of multivariate meta-analysis is implemented in the package mvmeta within the statistical environment R. As an illustrative example, we propose a two-stage analysis for investigating the non-linear exposure–response relationship between temperature and non-accidental mortality using time-series data from multiple cities. Multivariate meta-analysis represents a useful analytical tool for studying complex associations through a two-stage procedure. Copyright © 2012 John Wiley & Sons, Ltd.
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