Quinolone-resistant Shigella flexneri isolated in a patient who travelled to India.
Quinolone-resistant Shigella flexneri isolated in a patient who travelled to India.
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DOI：
10.3343/alm.2012.32.5.366
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发表时间：
2012-09
影响因子：
4.9
通讯作者：
Lee HJ
中科院分区：
文献类型：
--
作者：
Jeon YL;Nam YS;Lim G;Cho SY;Kim YT;Jang JH;Kim J;Park M;Lee HJ
我们报告最近一例从有印度旅行史的23岁女性患者中分离出耐环丙沙星的福氏志贺氏菌。在她进入我们的内科之前，她经历了高烧和全身虚弱的症状，这是在旅行中途出现的持续性水样腹泻。从粪便培养中分离出弗氏单胞菌。尽管最初用环丙沙星治疗，粪便培养继续显示弗氏沙门氏菌生长。在喹诺酮类抗生素的药敏试验中，该菌株对环丙沙星（最低抑菌浓度[MIC]为8µg/mL）、诺氟沙星（最低抑菌浓度为32µg/mL）、氧氟沙星（最低抑菌浓度为8µg/mL）、萘啶酸（最低抑菌浓度为256µg/mL）耐药，对左氧氟沙星（最低抑菌浓度为4µg/mL）耐药。在喹诺酮类耐药相关基因的分子研究中，未检测到质粒传播的喹诺酮类耐药基因qnrA、qnrB、qnrS、aac（6’）-Ib-cr、qepA、oqxAB等。gyrA有2个突变（248C→T, 259G→A）， parC有1个突变（239G→T）。该菌株的分子特征表明，该菌株与印度痢疾暴发分离的菌株比与韩国分离的菌株更相似。
We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our internal medicine department, she experienced symptoms of high fever and generalized weakness from continuous watery diarrhea that developed midway during the trip. S. flexneri was isolated from the stool culture. Despite initial treatment with ciprofloxacin, the stool cultures continued to show S. flexneri growth. In the susceptibility test for antibiotics of the quinolone family, the isolate showed resistance to ciprofloxacin (minimum inhibitory concentration [MIC], 8 µg/mL), norfloxacin (MIC, 32 µg/mL), ofloxacin (MIC, 8 µg/mL), nalidixic acid (MIC, 256 µg/mL), and intermediate resistance to levofloxacin (MIC, 4 µg/mL). In molecular studies for quinolone resistance related genes, plasmid borne-quinolone resistance genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, qepA, and oqxAB were not detected. Two mutations were observed in gyrA (248C→T, 259G→A) and 1 mutation in parC (239G→T). The molecular characteristics of the isolated S. flexneri showed that the isolate was more similar to the strains isolated from the dysentery outbreak in India than those isolated from Korea.
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影响因子：
4.2
作者：
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通讯作者：
Siitonen, A.
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4.9
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作者：
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Zechiedrich, Lynn
影响因子：
14.2
作者：
Kim, J. -Y.;Kim, S. -H.;Lee, B. -K.
通讯作者：
Lee, B. -K.