Heterogeneity of genetic architecture of body size traits in a free-living population.
Heterogeneity of genetic architecture of body size traits in a free-living population.
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自由生活群体体型特征遗传结构的异质性。
DOI：
10.1111/mec.13146
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发表时间：
2015-04
影响因子：
4.9
通讯作者：
Pemberton JM
中科院分区：
文献类型：
--
作者：
Bérénos C;Ellis PA;Pilkington JG;Lee SH;Gratten J;Pemberton JM
了解数量性状的潜在遗传结构有助于理解它们是如何进化的。在野生种群中，由于通常样本量小，标记面板分辨率低，复杂性状是多基因性状还是受少数具有主要影响的位点影响，在很大程度上仍然未知。在这里，我们使用37037个多态性SNPs研究了St Kilda上一个自由生活的Soay羊种群中5个成年体型特征的遗传结构。两个性状（下巴和体重）表现出多基因性状的典型特征：一条染色体解释的变异比例与其长度成正比，多条染色体和基因组区域解释了大量的表型变异，但在使用GWAS时，没有snp与性状变异相关。相比之下，腿长性状（前腿、后腿和掌骨）的遗传变异不成比例地由16号染色体（s23172.1）和19号染色体（s74894.1）上的两个snp解释，这两个snp分别解释了10%的加性遗传变异。在控制了环境差异后，s74894.1等位基因杂合的母羊在其一生中比具有长腿等位基因的母羊产生更多的羔羊和新生羊。我们还证明，赋予短腿的等位基因很可能是通过与邓菲斯羊的历史性混种事件进入人群的。总之，我们表明，不同的体型替代物可能具有非常不同的遗传结构，而密集的SNP有助于理解自然种群中数量性状的基因座的选择模式和进化史。
Knowledge of the underlying genetic architecture of quantitative traits could aid in understanding how they evolve. In wild populations, it is still largely unknown whether complex traits are polygenic or influenced by few loci with major effect, due to often small sample sizes and low resolution of marker panels. Here, we examine the genetic architecture of five adult body size traits in a free‐living population of Soay sheep on St Kilda using 37 037 polymorphic SNPs. Two traits (jaw and weight) show classical signs of a polygenic trait: the proportion of variance explained by a chromosome was proportional to its length, multiple chromosomes and genomic regions explained significant amounts of phenotypic variance, but no SNPs were associated with trait variance when using GWAS. In comparison, genetic variance for leg length traits (foreleg, hindleg and metacarpal) was disproportionately explained by two SNPs on chromosomes 16 (s23172.1) and 19 (s74894.1), which each explained >10% of the additive genetic variance. After controlling for environmental differences, females heterozygous for s74894.1 produced more lambs and recruits during their lifetime than females homozygous for the common allele conferring long legs. We also demonstrate that alleles conferring shorter legs have likely entered the population through a historic admixture event with the Dunface sheep. In summary, we show that different proxies for body size can have very different genetic architecture and that dense SNP helps in understanding both the mode of selection and the evolutionary history at loci underlying quantitative traits in natural populations.
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DOI：
10.1126/science.1165448
发表时间：
2009-03-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson TM;vonHoldt BM;Candille SI;Musiani M;Greco C;Stahler DR;Smith DW;Padhukasahasram B;Randi E;Leonard JA;Bustamante CD;Ostrander EA;Tang H;Wayne RK;Barsh GS
通讯作者：
Barsh GS
影响因子：
4.9
作者：
Coltman, DW;Pilkington, JG;Pemberton, JM
通讯作者：
Pemberton, JM
DOI：
10.1073/pnas.0903103106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Hindorff, Lucia A.;Sethupathy, Praveen;Manolio, Teri A.
通讯作者：
Manolio, Teri A.
DOI：
10.1126/science.1170587
发表时间：
2009-04-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chessa B;Pereira F;Arnaud F;Amorim A;Goyache F;Mainland I;Kao RR;Pemberton JM;Beraldi D;Stear MJ;Alberti A;Pittau M;Iannuzzi L;Banabazi MH;Kazwala RR;Zhang YP;Arranz JJ;Ali BA;Wang Z;Uzun M;Dione MM;Olsaker I;Holm LE;Saarma U;Ahmad S;Marzanov N;Eythorsdottir E;Holland MJ;Ajmone-Marsan P;Bruford MW;Kantanen J;Spencer TE;Palmarini M
通讯作者：
Palmarini M
影响因子：
64.8
作者：
通讯作者：
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