Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells.
Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells.
复制标题
寨卡病毒株可能在人类神经细胞中表现出不同的感染特征。
DOI：
10.1016/j.ebiom.2016.09.020
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发表时间：
2016-10
期刊：
影响因子：
11.1
通讯作者：
Salinas, Sara
中科院分区：
文献类型：
--
作者：
Simonin, Yannick;Loustalot, Fabien;Desmetz, Caroline;Foulongne, Vincent;Constant, Orianne;Fournier-Wirth, Chantal;Leon, Fanny;Moles, Jean-Pierre;Goubaud, Aurelien;Lemaitre, Jean-Marc;Maquart, Marianne;Leparc-Goffart, Isabelle;Briant, Laurence;Nagot, Nicolas;Van de Perre, Philippe;Salinas, Sara
The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes. Consistently, this African strain led to a higher infection rate and viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV. ZIKV from two Asian and African strains infect differentially IPSc-derived NSCs African ZIKV strain displays more infectivity and anti-viral response African and Asian ZIKV strains infect and replicate efficiently in human astrocytes Zika virus (ZIKV) is involved in a major epidemic in Latin America. Some neurological complications are reported following infection, in particular microcephaly and Guillain-Barré syndromes. Analyses show that one Asian and two Africans lineages exist. Although originally discovered in Africa in 1947, the actual epidemic is due to Asian ZIKV. Here, we compared the virulence of two African and Asian ZIKV strains in neural cells. We showed that in human neural stem cells, African ZIKV strain had a higher infectivity and triggered stronger cellular response. Altogether, our results highlight the need to better characterize ZIKV lineages to anticipate further epidemics.
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影响因子：
3.8
作者：
Dowall SD;Graham VA;Rayner E;Atkinson B;Hall G;Watson RJ;Bosworth A;Bonney LC;Kitchen S;Hewson R
通讯作者：
Hewson R
影响因子：
3.7
作者：
Beasley, DWC;Li, L;Barrett, ADT
通讯作者：
Barrett, ADT
影响因子：
5.4
作者：
Fazakerley, JK;Boyd, A;Kääriäinen, L
通讯作者：
Kääriäinen, L
影响因子：
3.8
作者：
Haddow AD;Schuh AJ;Yasuda CY;Kasper MR;Heang V;Huy R;Guzman H;Tesh RB;Weaver SC
通讯作者：
Weaver SC
DOI：
10.1016/0035-9203(52)90042-4
发表时间：
1952-01-01
影响因子：
2.2
作者：
DICK, GWA;KITCHEN, SF;HADDOW, AJ
通讯作者：
HADDOW, AJ