Immunopathophysiological aspects of an emerging neonatal infectious disease induced by a bacterial superantigen.
Immunopathophysiological aspects of an emerging neonatal infectious disease induced by a bacterial superantigen.
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由细菌超抗原诱导的新出现的新生儿传染病的免疫病理生理学方面。
DOI：
10.1172/jci10396
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Takehiko Uchiyama
中科院分区：
文献类型：
--
作者：
Naoto Takahashi;H. Kato;K. Imanishi;Keishi Miwa;Sadao Yamanami;Hiroshi Nishida;Takehiko Uchiyama
我们最近发现了一种新出现的新生儿传染病，新生儿中毒性休克综合征样（TSS样）疹性疾病（NTED），它是由耐甲氧西林金黄色葡萄球菌（MRSA）产生的超抗原TSS毒素-1 （TSST-1）诱导的。在这里，我们分析了NTED患者在急性期和恢复期以及暴露于MRSA的无症状婴儿中tsst -1反应性Vss2(+) T细胞的激活和反应。在急性期，Vss2(+) T细胞对TSST-1刺激无能，增殖明显，但发病2个月后，Vss2(+) T细胞数量下降至对照组的10%左右。虽然10例无症状新生儿MRSA携带者的Vss2(+) T细胞百分比在对照范围内，但根据Vss2(+) T细胞活化情况可将这些个体分为两组。其中3名婴儿（组1）的Vss2(+)CD4(+) T细胞高度表达CD45RO，对TSST-1无反应，而在其他7名无症状新生儿MRSA携带者（组2）中，这些细胞在对照水平表达CD45RO，对TSST-1刺激高度反应。1组4例急性期NTED患者和3例无症状新生儿MRSA携带者血清抗- tsst -1 IgG Ab滴度可忽略不计，而2组7例无症状感染者血清抗- tsst -1 IgG Ab滴度较高。我们认为母源性抗TSST-1 igg有助于抑制t细胞被TSST-1激活，保护婴儿不发生NTED。
We recently discovered an emerging neonatal infectious disease, neonatal toxic shock syndrome-like (TSS-like) exanthematous disease (NTED), which is induced by a superantigen, TSS toxin-1 (TSST-1), produced by methicillin-resistant Staphylococcus aureus (MRSA). Here, we analyzed the activation and the response of TSST-1-reactive Vss2(+) T cells in NTED patients during the acute and recovery phases and in asymptomatic infants exposed to MRSA. In the acute phase, Vss2(+) T cells were anergic to stimulation with TSST-1 and underwent marked expansion, but by 2 months after disease onset, their numbers had declined to about 10% of the control level. Although the percentage of Vss2(+) T cells in the ten asymptomatic neonatal MRSA carriers was within the control range, these individuals could be divided into two groups on the basis of Vss2(+) T-cell activation. Vss2(+)CD4(+) T cells from three of these infants (Group 1) highly expressed CD45RO and were anergic to TSST-1, whereas in the other seven asymptomatic neonatal MRSA carriers (Group 2), these cells expressed CD45RO at the control level and were highly responsive to stimulation with TSST-1. The serum anti-TSST-1 IgG Ab titer was negligible in the four NTED patients in the acute phase and the three asymptomatic neonatal MRSA carriers in Group 1, but it was high in the seven asymptomatic carriers in Group 2. We suggest that maternally derived anti-TSST-1 IgGs helps to suppress T-cell activation by TSST-1 and protects infants from developing NTED.
影响因子：
11.8
作者：
Archer, GL
通讯作者：
Archer, GL