Platelet effects on ovarian cancer.

Platelet effects on ovarian cancer.
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血小板对卵巢癌的影响。

DOI:
10.1053/j.seminoncol.2014.04.004
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发表时间:
2014-06
影响因子:
4
通讯作者:
Sood AK
Sood AK
中科院分区:
医学3区
文献类型:
--
作者:
Davis AN;Afshar-Kharghan V;Sood AK

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人们对血小板增多、高血小板周转率以及循环中活化血小板在癌症进展和转移中的作用的认识不断加深,使巨核细胞成为人们关注的焦点。血小板生物学对于止血、血管完整性、血管生成、炎症、先天免疫、伤口愈合和癌症生物学至关重要。然而,在考虑将巨核细胞/血小板定向疗法用于临床之前,需要了解恶性肿瘤中副肿瘤性血小板增多症的机制和生物学。在这里,我们概述了卵巢癌背景下副肿瘤性血小板增多症的临床意义、生物学意义和机制。
Growing understanding of the role of thrombocytosis, high platelet turnover, and the presence of activated platelets in the circulation in cancer progression and metastasis has brought megakaryocytes into focus. Platelet biology is essential to hemostasis, vascular integrity, angiogenesis, inflammation, innate immunity, wound healing, and cancer biology. However, before megakaryocyte/platelet-directed therapies can be considered for clinical use, understanding of the mechanism and biology of paraneoplastic thrombocytosis in malignancy is required. Here, we provide an overview of the clinical implications, biological significance, and mechanisms of paraneoplastic thrombocytosis in the context of ovarian cancer.
DOI: 10.1016/j.ygyno.2013.05.038
发表时间: 2013-09
影响因子: 4.7
作者:
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