More Than Mortar: Glia as Architects of Nervous System Development and Disease.
More Than Mortar: Glia as Architects of Nervous System Development and Disease.
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DOI：
10.3389/fcell.2020.611269
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发表时间：
2020
影响因子：
5.5
通讯作者：
Ackerman SD
中科院分区：
文献类型：
--
作者：
Lago-Baldaia I;Fernandes VM;Ackerman SD
神经胶质细胞是脊椎动物和无脊椎动物神经系统的重要组成部分。在人脑中，神经胶质细胞和神经元一样多，但神经胶质细胞对神经系统发育的几乎每个方面的重要性只是在过去几十年才得到阐述。现在已知胶质细胞调节神经特化、突触发生、突触功能，甚至宽电路功能。鉴于它们的普遍性，神经胶质细胞对神经元疾病发病机制的贡献是一个不断增长的研究领域，这并不奇怪。在这篇综述中，我们将总结神经胶质细胞参与神经系统发育和组织的几个不同阶段神经规范，电路布线和电路功能的积累证据。最后，我们将强调这些神经胶质细胞的早期发育作用如何有助于神经系统功能障碍的神经发育和神经退行性疾病。
Glial cells are an essential component of the nervous system of vertebrates and invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of glia to nearly every aspect of nervous system development has only been expounded over the last several decades. Glia are now known to regulate neural specification, synaptogenesis, synapse function, and even broad circuit function. Given their ubiquity, it is not surprising that the contribution of glia to neuronal disease pathogenesis is a growing area of research. In this review, we will summarize the accumulated evidence of glial participation in several distinct phases of nervous system development and organization—neural specification, circuit wiring, and circuit function. Finally, we will highlight how these early developmental roles of glia contribute to nervous system dysfunction in neurodevelopmental and neurodegenerative disorders.
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影响因子：
2.9
作者：
Ackerman SD;Monk KR
通讯作者：
Monk KR
DOI：
10.1085/jgp.80.1.19
发表时间：
1982-07
期刊：
The Journal of general physiology
影响因子：
--
作者：
Tsacopoulos M;Poitry S
通讯作者：
Poitry S
影响因子：
16.2
作者：
Agarwal A;Wu PH;Hughes EG;Fukaya M;Tischfield MA;Langseth AJ;Wirtz D;Bergles DE
通讯作者：
Bergles DE
影响因子：
16.2
作者：
Awasaki, T;Tatsumi, R;Ito, K
通讯作者：
Ito, K
影响因子：
9.9
作者：
ADELMAN, LS;ARONSON, M
通讯作者：
ARONSON, M