Maternal outcomes and risk factors for COVID-19 severity among pregnant women.
Maternal outcomes and risk factors for COVID-19 severity among pregnant women.
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DOI：
10.1038/s41598-021-92357-y
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发表时间：
2021-07-06
影响因子：
4.6
通讯作者：
Panchaud A
中科院分区：
文献类型：
--
作者：
Vouga M;Favre G;Martinez-Perez O;Pomar L;Acebal LF;Abascal-Saiz A;Hernandez MRV;Hcini N;Lambert V;Carles G;Sichitiu J;Salomon L;Stirnemann J;Ville Y;de Tejada BM;Goncé A;Hawkins-Villarreal A;Castillo K;Solsona EG;Trigo L;Cleary B;Geary M;Bartels H;Al-Kharouf F;Malone F;Higgins M;Keating N;Knowles S;Poncelet C;Ribeiro-do-Valle CC;Surita F;Dantas-Silva A;Borrelli C;Luz AG;Fuenzalida J;Carvajal J;Canales MG;Hernandez O;Grechukhina O;Ko AI;Reddy U;Figueiredo R;Moucho M;Pinto PV;De Luca C;De Santis M;de Campos DA;Martins I;Garabedian C;Subtil D;Bohrer B;Da Rocha Oppermann ML;Wender MCO;Schuler-Faccini L;Sanseverino MTV;Giugliani C;Friedrich L;Scherer MH;Mottet N;Ducarme G;Pelerin H;Moreau C;Breton B;Quibel T;Rozenberg P;Giannoni E;Granado C;Monod C;Mueller D;Hoesli I;Bassler D;Heldstab S;Kölble NO;Sentilhes L;Charvet M;Deprest J;Richter J;Van der Veeken L;Eggel-Hort B;Plantefeve G;Derouich M;Calvache AJN;Lopez-Giron MC;Burgos-Luna JM;Escobar-Vidarte MF;Hecher K;Tallarek AC;Hadar E;Haratz KK;Amikam U;Malinger G;Maymon R;Yogev Y;Schäffer L;Toussaint A;Rossier MC;De Sa RAM;Grawe C;Aebi-Popp K;Radan AP;Raio L;Surbek D;Böckenhoff P;Strizek B;Kaufmann M;Bloch A;Boulvain M;Johann S;Heldstab SA;Bernasconi MT;Grant G;Feki A;Brochut AM;Giral M;Sedille L;Papadia A;Brugger RC;Weber B;Fischer T;Kahlert C;Saines KN;Cambou M;Kanellos P;Chen X;Yin M;Haessig A;Ackermann S;Baud D;Panchaud A
孕妇患严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）相关严重并发症的风险可能更高，这可能导致产科并发症。我们进行了一项病例对照研究，比较了2020年3月24日至7月26日期间在COVI-Preg国际登记队列中登记的患有严重冠状病毒病19（病例）的孕妇与患有较轻形式（对照）的孕妇。危险因素的严重程度，产科和立即新生儿的结果进行了评估。共有926名SARS-CoV-2检测阳性的孕妇被纳入，其中92名（9.9%）患有严重的COVID-19疾病。重度母体结局的风险因素为肺部合并症[aOR 4.3，95% CI 1.9-9.5]、高血压疾病[aOR 2.7，95% CI 1.0-7.0]和糖尿病[aOR 2.2，95% CI 1.1-4.5]。重度孕产妇结局的孕妇剖腹产[70.7%（n = 53/75）]、早产[62.7%（n = 32/51）]和新生儿需要入住新生儿重症监护室[41.3%（n = 31/75）]的风险较高。在这项研究中，确定了孕妇发生SARS-CoV-2感染严重并发症的几个风险因素，包括肺部合并症、高血压疾病和糖尿病。产科和新生儿的结果似乎受到母亲疾病严重程度的影响。
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.
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影响因子：
4.3
作者：
Collin, Julius;Bystrom, Emma;Ahrne, Malin
通讯作者：
Ahrne, Malin
影响因子：
11.8
作者：
Wang, Shaoshuai;Guo, Lili;Feng, Ling
通讯作者：
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影响因子：
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作者：
Petrilli, Christopher M.;Jones, Simon A.;Horwitz, Leora I.
通讯作者：
Horwitz, Leora I.
影响因子：
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作者：
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通讯作者：
Wu, Jianli
DOI：
10.1111/1471-0528.16403
发表时间：
2020-08-13
影响因子：
5.8
作者：
Prabhu, M.;Cagino, K.;Riley, L. E.
通讯作者：
Riley, L. E.