Molecular epidemiology of group A streptococcus M type 1 infections.

Molecular epidemiology of group A streptococcus M type 1 infections.
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A 族链球菌 M 1 型感染的分子流行病学。

DOI:
10.1093/infdis/167.5.1112
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发表时间:
1993
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Leigh A. Single
Leigh A. Single
中科院分区:
--
文献类型:
--
作者:
Diana R. Martin;Leigh A. Single

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数据进行了审查约665链球菌M型1型菌株收到的链球菌参考实验室的新西兰传染病中心在1980年和1991年之间。分离株由新西兰各地的诊断实验室自愿提交,作为链球菌感染监测系统的一部分。在研究期间,M 1型的分布是不均匀的,发生了两波感染,每一波都有独特的疾病模式。使用限制性片段长度多态性(RFLP)分析的分子分型被用来研究从不同的地理位置,每年研究随机选择的菌株之间的系统发育关系。虽然有六种不同的RFLP模式,但大多数菌株(74%),包括两个波的菌株,属于1a型。在来自澳大利亚和美国的其他分离株中也发现了这种类型和另一种类型。20世纪80年代后期在美国和新西兰发生的严重侵袭性疾病病例的分型分离株属于RFLP 1a型。
Data were reviewed about 665 streptococcus M type 1 isolates received by the Streptococcus Reference Laboratory of the New Zealand Communicable Disease Centre between 1980 and 1991. Isolates were voluntarily submitted by diagnostic laboratories throughout New Zealand as part of a surveillance system for streptococcal infections. Over the study period, distribution of M type 1 was uneven, and two waves of infections occurred, each with a distinctive disease pattern. Molecular typing using restriction fragment length polymorphism (RFLP) analysis was used to examine phylogenetic relationships among isolates randomly selected from different geographic locations for each of the years studied. Although six distinct RFLP patterns occurred, most isolates (74%), including those of both waves, belonged to type 1a. This type and one other were also identified among additional isolates originating from Australia and the United States. Typed isolates from cases of severe invasive disease occurring both in the United States and in New Zealand in the late 1980s belonged to RFLP type 1a.
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影响因子: 11.1
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