Associations between back pain across adulthood and spine shape in early old age in a British birth cohort.
Associations between back pain across adulthood and spine shape in early old age in a British birth cohort.
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DOI：
10.1038/s41598-018-34628-9
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发表时间：
2018-11-05
影响因子：
4.6
通讯作者：
Cooper R
中科院分区：
文献类型：
--
作者：
Muthuri SG;Pavlova AV;Saunders FR;Hardy RJ;Gregory JS;Barr RJ;Martin KR;Adams JE;Kuh D;Aspden RM;Cooper R
我们的目的是研究成年后的背痛是否与60-64岁的脊柱形状有关。数据来自MRC国家健康与发展调查的1405名参与者，这是一个具有全国代表性的英国出生队列。背痛是在36岁、43岁、53岁和60-64岁的护士访谈中确定的。通过计算报告背痛的年龄，得出背痛的累积暴露量。统计形状建模用于使用侧位双能X线吸收测量法图像（在60-64岁时确定）确定胸腰椎脊柱形状。使用线性回归模型来测试脊柱形状模式（SM）与以下因素的关联：（1）累积背痛暴露;（2）成年期不同时期的背痛报告。在调整性别后，成年期背痛的累积暴露量较高与两种性别的楔形L4-5椎间盘（SM 4评分较低）和较小的椎间盘间隙（SM 8评分较高）相关。此外，在男性中，53岁和/或60-64岁时报告的背痛与L4-5椎间隙较小（SM 6评分较低）相关，但与女性无关。这些发现表明，成年后的背痛可能与老年早期脊柱形状的特定变化有关。
We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse interviews at ages 36, 43, 53 and 60–64 years. Cumulative exposure to back pain was then derived by counting the number of ages at which back pain was reported. Statistical shape modelling was used to characterise thoracolumbar spine shape using lateral dual-energy x-ray absorptiometry images which were ascertained at age 60–64 years. Linear regression models were used to test associations of spine shape modes (SM) with: (1) cumulative exposure to back pain; (2) back pain reports during different periods of adulthood. After adjusting for sex, higher cumulative exposure to back pain across adulthood was associated with wedge-shaped L4-5 disc (lower SM4 scores) and smaller disc spaces (higher SM8 scores) in both sexes. In addition, reporting of back pain at ages 53 and/or 60–64 years was associated with smaller L4-5 disc space (lower SM6 scores) in men but not women. These findings suggest that back pain across adulthood may be associated with specific variations in spine shapes in early old age.
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影响因子：
7.4
作者：
Muthuri SG;Kuh D;Cooper R
通讯作者：
Cooper R
影响因子：
3
作者：
Gore, DR
通讯作者：
Gore, DR
DOI：
10.1016/j.berh.2010.10.002
发表时间：
2010-12-01
影响因子：
5.2
作者：
Hoy, D.;Brooks, P.;Buchbinder, R.
通讯作者：
Buchbinder, R.
影响因子：
6.9
作者：
GOLDBERG, DP;HILLIER, VF
通讯作者：
HILLIER, VF
DOI：
10.1001/jama.2016.16885
发表时间：
2016-12-27
期刊：
JAMA
影响因子：
--
作者：
Dieleman JL;Baral R;Birger M;Bui AL;Bulchis A;Chapin A;Hamavid H;Horst C;Johnson EK;Joseph J;Lavado R;Lomsadze L;Reynolds A;Squires E;Campbell M;DeCenso B;Dicker D;Flaxman AD;Gabert R;Highfill T;Naghavi M;Nightingale N;Templin T;Tobias MI;Vos T;Murray CJ
通讯作者：
Murray CJ