What causes racial disparities in very preterm birth? A biosocial perspective.
What causes racial disparities in very preterm birth? A biosocial perspective.
复制标题
DOI：
10.1093/ajerev/mxp003
复制
发表时间：
2009
影响因子：
5.5
通讯作者：
Hogue CR
中科院分区：
文献类型：
--
作者：
Kramer MR;Hogue CR
极早产（<32周妊娠）发生在大约2%的活产婴儿中，但在美国是婴儿死亡和发病的主要原因。非洲裔美国妇女的风险比非西班牙裔白色妇女高2- 3倍，原因尚不完全清楚。本文回顾了极早产的生物和社会模式的证据，注意到领先的假设，关于种族差异的病因。对MEDLINE、CINAHL、PsycInfo和EMBASE索引中的文献进行了系统综述。迄今为止的文献提出了一个复杂的，多因素的因果关系框架，以了解种族差异，在非常早产，产妇炎症，血管或神经内分泌功能障碍的近端途径和产妇暴露于压力，种族差异的孕前健康，遗传，表观遗传和基因-环境相互作用作为更远的介质。人际关系和制度化的种族主义是可能驱动种族模式差异的机制。目前的文献是有限的，社会决定因素和生物过程的早产研究已普遍断开。更好地整合这些研究方法可能会提高对病因学的理解和有效干预的潜力。
Very preterm birth (<32 weeks’ gestation) occurs in approximately 2% of live births but is a leading cause of infant mortality and morbidity in the United States. African-American women have a 2-fold to 3-fold elevated risk compared with non-Hispanic white women for reasons that are incompletely understood. This paper reviews the evidence for the biologic and social patterning of very preterm birth, with attention to leading hypotheses regarding the etiology of the racial disparity. A systematic review of the literature in the MEDLINE, CINAHL, PsycInfo, and EMBASE indices was conducted. The literature to date suggests a complex, multifactorial causal framework for understanding racial disparities in very preterm birth, with maternal inflammatory, vascular, or neuroendocrine dysfunction as proximal pathways and maternal exposure to stress, racial differences in preconceptional health, and genetic, epigenetic, and gene-environment interactions as more distal mediators. Interpersonal and institutionalized racism are mechanisms that may drive racially patterned differences. Current literature is limited in that research on social determinants and biologic processes of prematurity has been generally disconnected. Improved etiologic understanding and the potential for effective intervention may come with better integration of these research approaches.
登录
查看更多内容
影响因子：
6.2
作者：
Challis, JRG
通讯作者：
Challis, JRG
影响因子：
12.7
作者：
Collins, JW;David, RJ;Andes, S
通讯作者：
Andes, S
影响因子：
5
作者：
Basso, Olga;Wilcox, Allen J.;Weinberg, Clarice R.
通讯作者：
Weinberg, Clarice R.
影响因子：
2.3
作者：
Berg, C J;Wilcox, L S;d'Almada, P J
通讯作者：
d'Almada, P J
影响因子：
8
作者：
Alexander, GR;Kogan, M;Mor, J
通讯作者：
Mor, J