Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men.
Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men.
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DOI：
10.1371/journal.pone.0099846
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ouchi N
中科院分区：
文献类型：
--
作者：
Yuasa D;Ohashi K;Shibata R;Takeshita K;Kikuchi R;Takahashi R;Kataoka Y;Miyabe M;Joki Y;Kambara T;Uemura Y;Matsuo K;Hayakawa S;Hiramatsu-Ito M;Ito M;Ikeda N;Murohara T;Ouchi N
肥胖是心血管疾病的主要危险因素。最近的证据表明，脂肪源性激素（也称为脂肪因子）的失调与肥胖相关疾病（包括冠状动脉疾病（CAD））的发病机制有关。在这里，我们研究了脂肪因子C1 q/TNF相关蛋白（CTRP）1的循环水平是否与CAD的患病率相关。选择行冠状动脉造影的男性冠心病患者76例。64例健康男性受试者作为对照。采用酶联免疫吸附法测定血浆CTRP 1浓度。CTRP 1水平与收缩压（BP）和甘油三酯水平呈正相关，与HDL胆固醇水平呈负相关。CAD患者的血浆CTRP 1水平显著高于对照受试者（CAD：443.3±18.6 ng/ml，对照：307.8±21.5 ng/ml，p<0.001）。对体重指数、收缩压、血糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、脂联素和CTRP 1进行多因素Logistic回归分析，结果显示CTRP 1水平、收缩压和高密度脂蛋白胆固醇与CAD相关。我们的数据表明高CTRP 1水平与CAD患病率密切相关，表明CTRP 1代表了CAD的新生物标志物。
Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, is linked with the pathogenesis of obesity-related disorders including coronary artery disease (CAD). Here, we investigated whether circulating level of an adipokine C1q/TNF-related protein (CTRP) 1 is associated with the prevalence of CAD. Consecutive 76 male CAD patients were enrolled from inpatients that underwent coronary angiography. Sixty four healthy male subjects served as controls. Plasma CTRP1 concentration was determined by enzyme-linked immunosorbent assay. CTRP1 levels were correlated positively with systolic blood pressure (BP) and triglyceride levels, and negatively with HDL cholesterol levels in all subjects. Plasma levels of CTRP1 were significantly higher in CAD patients than in control subjects (CAD: 443.3±18.6 ng/ml, control: 307.8±21.5 ng/ml, p<0.001). Multiple logistic regression analysis with body mass index, systolic BP, glucose, total cholesterol, HDL cholesterol, triglyceride, adiponectin and CTRP1 revealed that CTRP1 levels, together with systolic BP and HDL cholesterol, correlated with CAD. Our data indicate the close association of high CTRP1 levels with CAD prevalence, suggesting that CTRP1 represents a novel biomarker for CAD.
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影响因子：
64.5
作者：
Moore KJ;Tabas I
通讯作者：
Tabas I
炎症和代谢疾病中的脂肪因子。
DOI：
10.1038/nri2921
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.0403760101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Wong, GW;Wang, J;Lodish, HF
通讯作者：
Lodish, HF
影响因子：
2.8
作者：
Long, Yong;Gracely, Edward J.;Liu, Longjian
通讯作者：
Liu, Longjian
影响因子：
4.8
作者：
Shibata R;Ouchi N;Takahashi R;Terakura Y;Ohashi K;Ikeda N;Higuchi A;Terasaki H;Kihara S;Murohara T
通讯作者：
Murohara T