CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
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DOI：
10.1038/ncomms7217
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发表时间：
2015-02-18
影响因子：
16.6
通讯作者：
Lang, Karl S.
中科院分区：
文献类型：
--
作者：
Khairnar, Vishal;Duhan, Vikas;Maney, Sathish Kumar;Honke, Nadine;Shaabani, Namir;Pandyra, Aleksandra A.;Seifert, Marc;Pozdeev, Vitaly;Xu, Haifeng C.;Sharma, Piyush;Baldin, Fabian;Marquardsen, Florian;Merches, Katja;Lang, Elisabeth;Kirschning, Carsten;Westendorf, Astrid M.;Hauessinger, Dieter;Lang, Florian;Dittmer, Ulf;Kueppers, Ralf;Recher, Mike;Hardt, Cornelia;Scheffrahn, Inka;Beauchemin, Nicole;Goethert, Joachim R.;Singer, Bernhard B.;Lang, Philipp A.;Lang, Karl S.
B细胞是抗病毒免疫防御所必需的，因为它们产生中和抗体，呈递抗原并维持淋巴结构。在这里，我们表明CEACAM 1的内在信号传导对于产生有效的B细胞应答是必不可少的。尽管CEACAM 1对B细胞增殖的影响有限，但CEACAM 1的表达通过BTK/Syk/NF-κ B轴诱导增殖的B细胞的存活。Ceacam 1 −/−小鼠中缺乏这种信号级联反应限制了B细胞的存活。在全身感染细胞病变性水泡性口炎病毒期间，Ceacam 1 −/−小鼠几乎不能诱导中和抗体反应，并在感染后早期死亡。因此，我们发现CEACAM 1是B细胞存活的关键调节因子，影响B细胞数量和保护性抗病毒抗体反应。 抗体应答由具有适当抗原特异性的B细胞的选择性存活调节。在这里，作者表明CEACAM 1在体内平衡和抗病毒反应期间对B细胞存活至关重要。
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1−/− mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1−/− mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses. Antibody responses are regulated by selective survival of B cells with proper antigen specificity. Here the authors show that CEACAM1 is critical for B-cell survival during homeostasis and antiviral responses.
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影响因子：
32.4
作者：
Chen L;Chen Z;Baker K;Halvorsen EM;da Cunha AP;Flak MB;Gerber G;Huang YH;Hosomi S;Arthur JC;Dery KJ;Nagaishi T;Beauchemin N;Holmes KV;Ho JW;Shively JE;Jobin C;Onderdonk AB;Bry L;Weiner HL;Higgins DE;Blumberg RS
通讯作者：
Blumberg RS
影响因子：
11.4
作者：
Dingjan, GM;Maas, A;Hendriks, RW
通讯作者：
Hendriks, RW
影响因子：
6.7
作者：
Honke N;Shaabani N;Zhang DE;Iliakis G;Xu HC;Häussinger D;Recher M;Löhning M;Lang PA;Lang KS
通讯作者：
Lang KS
影响因子：
5.5
作者：
Greicius, G;Severinson, E;Singer, BB
通讯作者：
Singer, BB
影响因子：
20.3
作者：
Horst, Andrea K.;Bickert, Thomas;Ritter, Uwe
通讯作者：
Ritter, Uwe