Gastrocnemius Muscle Lipids in Relation to Diet in Two Mouse Mutants, 129Re‐dy and A2G‐adr, with Abnormal Muscle Function
Gastrocnemius Muscle Lipids in Relation to Diet in Two Mouse Mutants, 129Re‐dy and A2G‐adr, with Abnormal Muscle Function
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两种肌肉功能异常的小鼠突变体 129Re-dy 和 A2G-adr 中腓肠肌脂质与饮食的关系
DOI：
10.1111/j.1471-4159.1985.tb05502.x
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发表时间：
1985
影响因子：
4.7
通讯作者：
D. Watts
中科院分区：
文献类型：
--
作者：
Tessio Rebello;D. Watts
翻译后摘要：从正常和营养不良（dy）的Bar Harbor，129 Re株小鼠腓肠肌的脂质进行了研究。给动物喂食含有3.1%或1.1%总热量的亚油酸的饲料。还对一种新的小鼠突变体A2 G-adr的肌肉进行了脂质分析，该突变体具有异常的肌肉功能，其特征在于翻正反应的发展受阻。这些动物仅饲喂“高”亚油酸饲料。无论饮食如何，129 Re ‐dy中的总脂质、三酰甘油和胆固醇均升高，而A2 G ‐adr的胆固醇水平显著较高。总磷（μg P/g肌肉）和胆固醇/磷脂比仅在dy菌株中升高。心磷脂在dy（“低”亚油酸饮食）和adr肌肉中升高，而磷脂酰胆碱仅在adr菌株中降低。亚油酸酯化的磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸升高，而花生四烯酸在磷脂酰丝氨酸在这两个突变体减少。所有三种磷脂中的二十二碳六烯酸（22：6）均降低，与饮食处理无关。adr菌株具有正常水平的这种脂肪酸。结果特别指出，在129 Re ‐dy突变体中，腓肠肌中长链多不饱和脂肪酸代谢异常;在adr突变体中，它们可能反映了肌肉线粒体数量的异常增加。
Abstract: The lipids of gastrocnemius muscle from normal and dystrophic (dy) mice of the Bar Harbor, 129Re strain were studied. Animals were fed diets containing either 3.1% or 1.1% of total calories as linoleic acid. Lipid analyses were also done on muscle from a new mouse mutant, A2G‐adr, which has abnormal muscle function, characterised by an arrested development of the righting response. These animals were fed the “high” linoleic acid diet only. Total lipid, triacylglycerol, and cholesterol were elevated in the 129Re‐dy irrespective of the diet, whereas A2G‐adr possessed significantly higher levels of cholesterol. Total phosphorus (μg P/g muscle) and cholesterol/phospholipid ratios were elevated in the dy strains only. Cardiolipin was raised in the dy (“low” linoleic diet) and adr muscle, whereas phosphatidylcholine was lower in the adr strain only. Linoleic acid esterified to phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine was elevated whereas arachidonic acid in phosphatidylserine was decreased in both mutants. Docosahexanoic acid (22:6) in all three dy phospholipids was decreased, independent of dietary treatment. The adr strain possessed normal levels of this fatty acid. The results specifically point to an abnormality in long‐chain polyunsaturated fatty acid metabolism in gastrocnemius muscle in the 129Re‐dy mutant; in the adr mutant they could reflect an abnormal increase in the number of muscle mitochondria.
影响因子：
6.5
作者：
W. R. Morrison;L. Smith
通讯作者：
W. R. Morrison;L. Smith