Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.
Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.
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DOI：
10.1101/lm.046698.117
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Hope BT
中科院分区：
文献类型：
--
作者：
Whitaker LR;Hope BT
鉴于成瘾被认为是一种不适应的学习和记忆障碍，一个关键的问题是，在支持成瘾相关学习行为的神经元群中，是否存在独特的物理适应。尽管已经进行了数十年的研究，但对这些记忆和其他记忆在大脑中编码的物理机制（通常被称为整个印痕）的探索仍在继续。随着我们开发出新的技术和工具，使我们能够研究线索和行为激活的fos表达神经元集合，识别学习和记忆印迹的可能性正在进入现实领域，而不是猜测。从最近的研究中可以清楚地看出，表达fos的集合神经元具有特定的功能和电生理变化，可能参与编码记忆。最终的目标是识别成瘾的印记，并逆转支持这种不适应学习形式的身体变化。
Given that addiction has been characterized as a disorder of maladaptive learning and memory, one critical question is whether there are unique physical adaptations within neuronal ensembles that support addiction-related learned behavior. The search for the physical mechanisms of encoding these and other memories in the brain, often called the engram as a whole, continues despite decades of research. As we develop new technologies and tools that allow us to study cue- and behavior-activated Fos-expressing neuronal ensembles, the possibility of identifying the engrams of learning and memory is moving into the realm of reality rather than speculation. It has become clear from recent studies that there are specific functional, electrophysiological alterations unique to Fos-expressing ensemble neurons that may participate in encoding memories. The ultimate goal is to identify the addicted engram and reverse the physical changes that support this maladaptive form of learning.
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DOI：
10.1523/jneurosci.1914-12.2012
发表时间：
2012-08-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fanous S;Goldart EM;Theberge FR;Bossert JM;Shaham Y;Hope BT
通讯作者：
Hope BT
影响因子：
25
作者：
Bossert, Jennifer M.;Stern, Anna L.;Theberge, Florence R. M.;Cifani, Carlo;Koya, Eisuke;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin
影响因子：
5.3
作者：
Barth, AL;Gerkin, RC;Dean, KL
通讯作者：
Dean, KL
影响因子：
16.2
作者：
Bowers, M. Scott;Chen, Billy T.;Bonci, Antonello
通讯作者：
Bonci, Antonello
影响因子：
2.9
作者：
CARELLI, RM;KING, VC;DEADWYLER, SA
通讯作者：
DEADWYLER, SA