Mapping and correction of vascular hemodynamic latency in the BOLD signal.

Mapping and correction of vascular hemodynamic latency in the BOLD signal.
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DOI:
10.1016/j.neuroimage.2008.06.030
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发表时间:
2008-10-15
期刊:
影响因子:
5.7
通讯作者:
Glover, Gary H.
Glover, Gary H.
中科院分区:
医学1区
文献类型:
--
作者:
Chang, Catie;Thomason, Moriah E.;Glover, Gary H.

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相关性和因果性度量可以应用于血氧水平依赖(BOLD)信号时间序列,以便从fMRI数据中推断神经同步性和信息流方向。然而,BOLD信号既反映了潜在的神经活动,也反映了血管反应,后者由局部血管运动生理学控制。因此,潜在的血管潜伏期差异的存在在神经同步性的检测以及神经过程的因果关系的推断中造成了混乱。在目前的研究中,我们调查了屏气(BH)任务的使用来表征和纠正整个大脑中体素方向的神经血管潜伏期差异。我们证明了BH可以可靠地测量体素之间的相对时序差异,并进一步表明BH导出的校正可以影响静息状态默认模式网络的功能连通性图和事件相关工作记忆(WM)任务的激活图。
Correlation and causality metrics can be applied to blood-oxygen level dependent (BOLD) signal time series in order to infer neural synchrony and directions of information flow from fMRI data. However, the BOLD signal reflects both the underlying neural activity and the vascular response, the latter of which is governed by local vasomotor physiology. The presence of potential vascular latency differences thus poses a confound in the detection of neural synchrony as well as inferences about the causality of neural processes. In the present study, we investigate the use of a breath holding (BH) task for characterizing and correcting for voxel-wise neurovascular latency differences across the whole brain. We demonstrate that BH yields reliable measurements of relative timing differences between voxels, and further show that a BH-derived correction can impact both functional connectivity maps of the resting-state default-mode network and activation maps of an event-related working memory (WM) task.
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