Post-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic.
Post-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic.
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危重 COVID-19 后重症监护后综合征：比利时一家随访诊所的队列研究。
DOI：
10.1186/s13613-021-00910-9
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发表时间：
2021-07-29
影响因子：
8.1
通讯作者：
Misset B
中科院分区：
文献类型：
--
作者：
Rousseau AF;Minguet P;Colson C;Kellens I;Chaabane S;Delanaye P;Cavalier E;Chase JG;Lambermont B;Misset B
许多2019冠状病毒病（COVID-19）患者需要重症监护。需要对幸存者的中期结果进行评估。本单中心队列研究的目的是描述重症监护病房（ICU）出院后3个月的身体、认知、心理和生物学结果。所有在ICU住院≥7天并在我们的多学科随访诊所参加M3会诊的COVID-19成年人均被纳入研究。他们受益于标准化的评估，涉及健康相关的生活质量（EQ-5D-3L）、睡眠障碍（PSQI）和重症监护综合征（PICS）的三个主要组成部分：身体状况（Barthel指数、握力和股四头肌力量）、精神健康障碍（HADS和ees -r）和认知障碍（MoCA）。生物学参数为c反应蛋白和肌酐。在我们ICU收治的92例COVID-19患者中，42例延长ICU住院时间，32例（80%）参加了M3随访。他们的中位年龄为62岁[49-68]岁，72%为男性，近一半患者出院后接受了住院康复。在M3时，87.5%（28/32）的患者没有恢复到日常活动的基线水平。只有6.2%（2/32）患者完全康复，且MoCA、IES-R和Barthel三项评分正常。观察到的主要障碍为PSQI bbb5（75%, 24/32）、MoCA < 26（44%, 14/32）、Barthel < 100（31%, 10/32）和IES-R≥33（28%,9/32）。合并疾病13/32（40.6%）。EQ-5D-3L视觉评分为71分[61-80]。四分之一的患者（8/32）表现出持续炎症，基于血液CRP水平（9.3 [6.8-17.7]mg/L）。在本队列中，重症COVID-19和延长ICU住院时间在3个月后的负担相当大，影响了功能状态和生物学参数。这些数据证明了对COVID-19危重幸存者进行密切随访的必要性。在线版本包含补充材料，可在10.1186/s13613-021-00910-9获得。
Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their physical, cognitive, psychological, and biological outcomes at 3 months following intensive care unit (ICU)-discharge (M3). All COVID-19 adults who survived an ICU stay ≥ 7 days and attended the M3 consultation at our multidisciplinary follow-up clinic were involved. They benefited from a standardized assessment, addressing health-related quality of life (EQ-5D-3L), sleep disorders (PSQI), and the three principal components of post-intensive care syndrome (PICS): physical status (Barthel index, handgrip and quadriceps strength), mental health disorders (HADS and IES-R), and cognitive impairment (MoCA). Biological parameters referred to C-reactive protein and creatinine. Among the 92 patients admitted to our ICU for COVID-19, 42 survived a prolonged ICU stay and 32 (80%) attended the M3 follow-up visit. Their median age was 62 [49–68] years, 72% were male, and nearly half received inpatient rehabilitation following ICU discharge. At M3, 87.5% (28/32) had not regained their baseline level of daily activities. Only 6.2% (2/32) fully recovered, and had normal scores for the three MoCA, IES-R and Barthel scores. The main observed disorders were PSQI > 5 (75%, 24/32), MoCA < 26 (44%, 14/32), Barthel < 100 (31%, 10/32) and IES-R ≥ 33 (28%, 9/32). Combined disorders were observed in 13/32 (40.6%) of the patients. The EQ-5D-3L visual scale was rated at 71 [61–80]. A quarter of patients (8/32) demonstrated a persistent inflammation based on CRP blood level (9.3 [6.8–17.7] mg/L). The burden of severe COVID-19 and prolonged ICU stay was considerable in the present cohort after 3 months, affecting both functional status and biological parameters. These data are an argument on the need for closed follow-up for critically ill COVID-19 survivors. The online version contains supplementary material available at 10.1186/s13613-021-00910-9.
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DOI：
10.1186/cc10121
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
Sacanella E;Pérez-Castejón JM;Nicolás JM;Masanés F;Navarro M;Castro P;López-Soto A
通讯作者：
López-Soto A
影响因子：
3.3
作者：
Blanjean, Arielle;Kellens, Isabelle;Rousseau, Anne-Francoise
通讯作者：
Rousseau, Anne-Francoise
影响因子：
8.8
作者：
Norman, Brett C.;Jackson, James C.;Ely, E. Wesley
通讯作者：
Ely, E. Wesley
DOI：
10.1186/cc8848
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cuthbertson BH;Roughton S;Jenkinson D;Maclennan G;Vale L
通讯作者：
Vale L
影响因子：
15.1
作者：
Grieco, Domenico Luca;Bongiovanni, Filippo;Antonelli, Massimo
通讯作者：
Antonelli, Massimo