Quality of life in the five years after intensive care: a cohort study.
Quality of life in the five years after intensive care: a cohort study.
复制标题
DOI：
10.1186/cc8848
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Vale L
中科院分区：
文献类型：
--
作者：
Cuthbertson BH;Roughton S;Jenkinson D;Maclennan G;Vale L
有关重症监护出院后2年以上生活质量的数据有限，我们的目标是进一步探索这一领域。我们的目标是量化重症监护出院后5年内的生活质量和卫生设施。英国一所大学医院的前瞻性纵向队列研究。生活质量评估从ICU入院前到5年，并计算质量调整后的生命年。纳入300例三级重症监护患者，平均年龄60.5岁，平均住院时间6.7d。躯体生活质量下降至3个月(P=0.003)，12个月回升至发病前水平，重症监护后从2.5年至5年再次下降(P=0.002)。在所有时间点，平均身体评分均低于人群常模，但6个月后的平均心理评分与人群常模相近。使用EuroQol-5D生活质量评估工具(EQ-5D)在5年时测得的效用值为0.677。在重症监护病房后的五年中，累积质量调整寿命年显著低于普通人群的预期寿命年(P<；0.001)。重症监护病房入院与高死亡率、较差的身体生活质量和较低质量的调整后生命年相比，在出院后5年内与普通人群相比。在这一组中，与ICU入院相关的危重疾病应该被视为终生诊断，并伴随着相关的过高死亡率、发病率和对持续医疗支持的需求。
Data on quality of life beyond 2 years after intensive care discharge are limited and we aimed to explore this area further. Our objective was to quantify quality of life and health utilities in the 5 years after intensive care discharge. A prospective longitudinal cohort study in a University Hospital in the UK. Quality of life was assessed from the period before ICU admission until 5 years and quality adjusted life years calculated. 300 level 3 intensive care patients of median age 60.5 years and median length of stay 6.7 days, were recruited. Physical quality of life fell to 3 months (P = 0.003), rose back to pre-morbid levels at 12 months then fell again from 2.5 to 5 years after intensive care (P = 0.002). Mean physical scores were below the population norm at all time points but the mean mental scores after 6 months were similar to those population norms. The utility value measured using the EuroQOL-5D quality of life assessment tool (EQ-5D) at 5 years was 0.677. During the five years after intensive care unit, the cumulative quality adjusted life years were significantly lower than that expected for the general population (P < 0.001). Intensive care unit admission is associated with a high mortality, a poor physical quality of life and a low quality adjusted life years gained compared to the general population for 5 years after discharge. In this group, critical illness associated with ICU admission should be treated as a life time diagnosis with associated excess mortality, morbidity and the requirement for ongoing health care support.
登录
查看更多内容
DOI：
10.1186/cc5070
发表时间：
2006
期刊：
Critical care (London, England)
影响因子：
--
作者：
Deja M;Denke C;Weber-Carstens S;Schröder J;Pille CE;Hokema F;Falke KJ;Kaisers U
通讯作者：
Kaisers U
影响因子：
8.8
作者：
Angus, DC;Linde-Zwirble, WT;van Hout, B
通讯作者：
van Hout, B
DOI：
10.1017/s0266462306050884
发表时间：
2006-12-01
影响因子：
3.2
作者：
Green, C;Dinnes, J;Cuthbertson, BH
通讯作者：
Cuthbertson, BH
影响因子：
8.8
作者：
Halpern, NA;Pastores, SM;Greenstein, RJ
通讯作者：
Greenstein, RJ
影响因子：
10.7
作者：
Chrispin, PS;Scotton, H;Ridley, SA
通讯作者：
Ridley, SA