Metagenomic approaches to natural products from free-living and symbiotic organisms.

Metagenomic approaches to natural products from free-living and symbiotic organisms.
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DOI:
10.1039/b817078a
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发表时间:
2009-11
影响因子:
11.9
通讯作者:
Schmidt EW
Schmidt EW
中科院分区:
化学1区
文献类型:
--
作者:
Brady SF;Simmons L;Kim JH;Schmidt EW

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在过去的80年里,细菌培养一直是天然产物发现的支柱。然而,大多数细菌不愿培养,为新的天然产品提供了一个尚未开发的来源。元基因组分析为天然产物研究和发现新的生物活性物质提供了一种直接获取未培养基因组的替代方法。描述了元基因组学在不同生境中的应用,如土壤和动物体内。
Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.
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