Metagenomic approaches to natural products from free-living and symbiotic organisms.
Metagenomic approaches to natural products from free-living and symbiotic organisms.
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DOI:
10.1039/b817078a
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发表时间:
2009-11
影响因子:
11.9
通讯作者:
Schmidt EW
中科院分区:
文献类型:
--
作者:
Brady SF;Simmons L;Kim JH;Schmidt EW
Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.
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影响因子:
1.6
作者:
Davidson, SK;Haygood, MG
通讯作者:
Haygood, MG
影响因子:
7.3
作者:
DEGNAN, BM;HAWKINS, CJ;WATTERS, DJ
通讯作者:
WATTERS, DJ
影响因子:
14.8
作者:
Donia, Mohamed S.;Hathaway, Brian J.;Schmidt, Eric W.
通讯作者:
Schmidt, Eric W.
影响因子:
15
作者:
Brady, Sean F.;Bauer, John D.;Daniels, Rachel
通讯作者:
Daniels, Rachel
影响因子:
14.8
作者:
Brady, Sean F.
通讯作者:
Brady, Sean F.