Obesity as an emerging risk factor for iron deficiency.
Obesity as an emerging risk factor for iron deficiency.
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肥胖是铁缺乏症的新兴危险因素。
DOI：
10.3390/nu6093587
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发表时间：
2014-09-11
期刊：
影响因子：
5.9
通讯作者：
Datz C
中科院分区：
文献类型：
--
作者：
Aigner E;Feldman A;Datz C
铁稳态受到肥胖和肥胖相关的胰岛素抵抗的影响，在许多方面的方式。一方面，铁缺乏和贫血是肥胖进展阶段的受试者的常见发现。这一现象在肥胖青少年、女性和接受减肥手术的受试者中得到了充分研究。另一方面，在大约三分之一的代谢综合征（MetS）或非酒精性脂肪肝（NAFLD）患者中观察到转铁蛋白饱和度正常或轻度升高的高铁蛋白血症。这种现象被称为“代谢异常铁过载综合征（DIOS）”。无论是体内铁储备升高和缺铁都对健康和肥胖相关疾病的过程有害。缺铁和贫血可能损害线粒体和细胞能量稳态，并进一步增加肥胖受试者的不活动和疲劳。肥胖相关性炎症与铁缺乏密切相关，并涉及与十二指肠铁转运蛋白（FPN）低表达相关的十二指肠铁吸收受损以及铁调素浓度升高沿着。本文综述了目前对肥胖患者体内铁稳态失调的认识。
Iron homeostasis is affected by obesity and obesity-related insulin resistance in a many-facetted fashion. On one hand, iron deficiency and anemia are frequent findings in subjects with progressed stages of obesity. This phenomenon has been well studied in obese adolescents, women and subjects undergoing bariatric surgery. On the other hand, hyperferritinemia with normal or mildly elevated transferrin saturation is observed in approximately one-third of patients with metabolic syndrome (MetS) or nonalcoholic fatty liver disease (NAFLD). This constellation has been named the “dysmetabolic iron overload syndrome (DIOS)”. Both elevated body iron stores and iron deficiency are detrimental to health and to the course of obesity-related conditions. Iron deficiency and anemia may impair mitochondrial and cellular energy homeostasis and further increase inactivity and fatigue of obese subjects. Obesity-associated inflammation is tightly linked to iron deficiency and involves impaired duodenal iron absorption associated with low expression of duodenal ferroportin (FPN) along with elevated hepcidin concentrations. This review summarizes the current understanding of the dysregulation of iron homeostasis in obesity.
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